长链非编码RNA结肠癌相关转录因子1与胃癌的研究进展  

Research progress of long non-coding RNA CCAT1 and gastric cancer

作　　者：贺林 程龙 周程继[1] 王攀[1] HE Lin;CHENG Long;ZHOU Chengji;WANG Pan(Department of Gastrointestinal Surgery,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China)

机构地区：[1]川北医学院附属医院胃肠外科,四川南充637000

出　　处：《中国普外基础与临床杂志》2020年第9期1180-1183,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：南充市市校科技战略合作项目(编号:18SXHZ0110)。

摘　　要：目的了解长链非编码RNA(lncRNA)结肠癌相关转录因子1(CCAT1)的功能并总结其与胃癌发生及发展的关系。方法对近年来发表的关于lncRNA CCAT1的功能研究及其与胃癌关系研究的文献进行综述与分析。结果lncRNA CCAT1通过作为竞争性内源性RNA与微小RNAs(microRNAs,miR)结合对基因产生负调控作用,介导c-MYC启动子与其上游增强子之间的染色质循环并促进c-MYC基因的表达,新近研究发现CCAT1可与miR-219-1、miR-490结合从而促进胃癌的进展。lncRNA CCAT1在胃癌组织中表达增高,与癌旁组织、正常组织中的表达存在明显差异,其高表达与肿瘤的大小、淋巴结转移和TNM分期有关。结论CCAT1参与胃癌进展的具体机制、胞内信号转导途径、与其他分子的相互作用机制仍需进一步探索,随着对lncRNA特别是CCAT1的深入研究,可能为CCAT1作为靶标用于胃癌的诊断及治疗提供更加广阔的前景。Objective To understand the function of long non-coding RNA(lncRNA)colon cancer associated transcript-1(CCAT1)and summarize its relationship with gastric cancer.Method The published literatures on the studies of lncRNA CCAT1 function and its relationship with gastric cancer were reviewed and analyzed.Results The lncRNA CCAT1 exerted the negative regulation on the genes by binding to microRNAs(miR)as a competitive endogenous RNA,mediating chromatin circulation between the c-MYC promoter and its upstream enhancer,and promoted the expression of c-MYC gene.The recent studies had found that the CCAT1 could bind to the miR-219-1 and miR-490,thereby promoting the progress of gastric cancer.The expression of lncRNA CCAT1 in the gastric cancer tissues increased,which was obviously different from that in the paracancer tissues and normal tissues.The high expression of lncRNA CCAT1 was related to the tumor size,lymphatic metastasis and TNM stage.Conclusions The specific mechanism,intracellular signal transduction pathway and interaction mechanism between CCAT1 and other molecules involved in the progress of gastric cancer still need to be further explored.With the in-depth study of lncRNA,especially CCAT1,it may provide a broader prospect for the diagnosis and treatment of gastric cancer as a target of CCAT1.

关 键 词：胃癌 长链非编码RNA 结肠癌相关转录因子1 微小RNA 

分 类 号：R735.2[医药卫生—肿瘤]