舍曲林联合心理治疗女童夹腿综合征的临床疗效分析  

Clinical analysis of sertraline combined with psychotherapy for female children with leg-pinch syndrome

作　　者：蒋国庆[1] 蔡飞亚 王敏建 JIANG Guoqing;CAI Feiya;WANG Minjian(Department of Children and Adolescents,Chongqing Mental Health Center,Chongqing 401147,China)

机构地区：[1]重庆市精神卫生中心儿童青少年科,401147

出　　处：《重庆医学》2020年第17期2893-2896,共4页Chongqing medicine

基　　金：重庆市精神卫生中心院级课题(2018-yjkt-01);重庆市精神卫生中心新兴培育学科建设项目(渝精卫发[2018]50号)。

摘　　要：目的观察舍曲林联合心理治疗女童夹腿综合征的临床疗效。方法选取44例女性夹腿综合征患儿随机分为对照组和治疗组,对照组22例只接受心理治疗,治疗组22例采用舍曲林联合心理治疗,于治疗前、治疗后4周和12周,以Spence儿童焦虑量表(SCAS)、Kovacs儿童抑郁量表(CDI)和临床疗效总评价量表(CGI)中的病情严重程度分量表(SI)评定疗效;于治疗后1、4、12周以TESS量表评定治疗组不良反应。结果两组分别脱落2例患者;与同时间点对照组比较,治疗组于治疗后4、12周SCAS、CDI和CGI得分均明显降低(P<0.01)。治疗4周后,治疗组SCAS、CDI和SI分值较治疗前明显降低(P<0.01);治疗12周较治疗4周明显降低(P<0.01);对照组治疗前,治疗后4、12周SCAS、CDI及SI量表得分差异无统计学意义(P>0.05)。治疗组治疗第4周和第12周每天夹腿行为平均发作次数少于对照组(P<0.05)。不良反应量表(TESS)评定治疗组主要不良反应为轻度镇静。结论舍曲林联合心理治疗对女童夹腿综合征治疗疗效好、安全性高。Objective To observe the clinical effect of sertraline combined with psychotherapy for female children with leg-pinch syndrome.Methods A total of 44 cases of girls with leg-pinch syndrome were randomly divided into the control group and the treatment group.The control group(n=22)received only psychotherapy,while the treatment group(n=22)received sertraline combined with psychotherapy.The curative effect was evaluated by the Spence children′s anxiety scale(SCAS),Kovacs children′s depression inventory(CDI)and severity of illness subscale(SI)[a subscale of Global Impression(CGI)]at the time of before treatment,4 weeks and 12 weeks after treatment.The adverse reaction of the treatment group were evaluated by treatment emergent symptom scale(TESS)at the time of 1,4 and 12 weeks after treatment.Results Two patients were dropped out respectively in the two groups;Compared with the control group,the scores of the SCAS,CDI and SI in the treatment group decreased significantly at 4 and 12 weeks after treatment(P<0.01).After 4 weeks of treatment,the scores of the SCAS,CDI and SI in the treatment group were significantly lower than those before treatment(P<0.01),and the 12 weeks after treatment were significantly lower than the 4 weeks after treatment(P<0.01).There was no significant difference in the scores of the three scales at three time points in the control group(P>0.05).The average number of occurrences of leg-pinch behavior per day in the treatment group was less than that of the control group at the time of 4 weeks and 12 weeks after treatment(P<0.05).Conclusion Sertraline combined with psychotherapy is effective and safe in the treatment of female children with leg-pinch syndrome.

关 键 词：舍曲林 夹腿综合征 神经发育障碍 治疗结果 

分 类 号：R749.94[医药卫生—神经病学与精神病学]