牙龈卟啉单胞菌菌毛蛋白介导动脉粥样硬化的研究进展  

Study on the mechanism of Porphyromonas gingivalis pili mediated atherosclerosis

作　　者：郭竹玲 刘莎莎 张羽 符起亚 GUO Zhu-Ling;LIU Sha-sha;ZHANG Yu;FU Qi-Ya(School of Stomatology, Hainan Medical University, Haikou 570100, PR China;Department of Stomatology, the First Affiliated Hospital of Hainan Medical University, Haikou 570102, PR China)

机构地区：[1]海南医学院口腔医学院,海南海口570100 [2]海南医学院第一附属医院口腔科,海南海口570102

出　　处：《海南医学院学报》2020年第18期1437-1440,共4页Journal of Hainan Medical University

基　　金：海南省高等学校科学研究重点项目(Hnky2018ZD-7);海南省科协青年科技英才学术创新计划项目(QCXM201817);海南省人文医学研究基地规划课题[QRYZH201811(YB)];海南医学院教育科学研究课题(HYYB202014)。

摘　　要：慢性牙周炎是由菌斑生物膜所引起的最常见的感染性牙周组织疾病,其主要致病菌是牙龈卟啉单胞菌。菌毛是牙龈卟啉单胞菌的重要菌体成分。流行病学研究表明,慢性牙周炎可增加心血管疾病的风险,动脉粥样硬化是心血管疾病的病理基础。本文对牙龈卟啉单胞菌菌毛蛋白介导慢性牙周炎和动脉粥样硬化的机制进行总结,以拓展疾病防治新思路。Chronic periodontitis is the most common infectious periodontal disease caused by plaque biofilm.Pili are important bacterial components of Porphyromonas gingivalis.Epidemiological studies have shown that chronic periodontitis can increase the risk of cardiovascular disease,and atherosclerosis is the pathological basis of cardiovascular disease.This article will summarize the mechanism of Porphyromonas gingivalis pili protein mediated chronic periodontitis and atherosclerosis,in order to develop new ideas of disease prevention and treatment.

关 键 词：牙龈卟啉单胞菌 菌毛 慢性牙周炎 动脉粥样硬化 

分 类 号：R781.42[医药卫生—口腔医学] R543.5[医药卫生—临床医学]