结直肠癌肝转移患者血清OPN、YKL-40、HGF和VEGF-A水平及其危险因素分析  

Detection of the Serum Levels of OPN, YKL-40, HGF, VEGF-A and the Risk Factors of Liver Metastasis in Patients with Colorectal Cancer

作　　者：陈云风 胡道军[1] 张旭[1] 李玉珍 沈宝岩 CHEN Yun-feng;HU Dao-jun;ZHANG Xu;LI Yu-zhen;SHEN Bao-yan(Clinical laboratory,Xinhua Hospital affiliated to Medical College of Shanghai Jiaotong University(Chongming),Shanghai,202150,China)

机构地区：[1]上海交通大学医学院附属新华医院(崇明)检验科,上海202150

出　　处：《现代生物医学进展》2020年第15期2891-2895,共5页Progress in Modern Biomedicine

基　　金：上海市崇明区科委研究项目(ckw2018-11)。

摘　　要：目的:检测结直肠癌肝转移患者血清骨桥蛋白(Osteopontin,OPN)、人类软骨糖蛋白-39(Human cartilage gp-39,YKL-40)、肝细胞生长因子(Hepatocyte growth factor,HGF)和血管内皮生长因子A(Vascular endothelial growth factor A,VEGF-A)水平,并分析直肠癌患者发生肝转移的危险因素。方法:收集56例发生肝转移的直结肠癌患者和50例未发生肝转移的直结肠癌患者,采用酶联免疫法检测两组患者血清OPN、YKL-40、HGF和VEGF-A的水平。收集所有患者的临床资料,分析直肠癌患者发生肝转移的危险因素。结果:结直肠癌肝转移患者血清OPN、YKL-40、HGF和VEGF-A水平均显著高于未发生肝转移的直结肠癌患者(P>0.05);糖尿病、肿瘤最大直径、病理类型、分化程度、浸润深度、淋巴结转移、盆腹膜种植、肝外转移、吸烟史均与结直肠癌发生肝转移相关(P<0.05);而HGF、VEGF-A、糖尿病、肿瘤最大直径≥5 cm、淋巴结转移、盆腹膜种植、肝外转移是直肠癌发生肝转移的独立危险因素(P<0.05)。结论:结直肠癌肝转移患者血清OPN、YKL-40、HGF和VEGF-A明显升高,HGF、VEGF-A、糖尿病、肿瘤最大直径≥5 cm、淋巴结转移、盆腹膜种植、肝外转移是直肠癌发生肝转移的独立危险因素。Objective: To detect the serum levels of osteopontin(OPN), human cartilage glycoprotein 39(YKL-40), hepatocyte growth factor(HGF) and vascular endothelial growth factor A(VEGF-A) in colorectal cancer patients withliver metastasis, and analyze the risk factors of liver metastasis in patients with colorectal cancer. Methods: The serum levels of OPN, YKL-40, HGF and VEGF-A were detected by enzyme linked immunosorbent assay in 56 straight colon cancer patients with liver metastasis and 50 straight colon cancer patients without liver metastasis. The clinical data of all patients were collected to analyze the risk factors of liver metastasis in rectal cancer patients. Results: The serum OPN, YKL-40, HGF and VEGF-A levels in the colorectal cancer patients with liver metastasis were significantly higher than those in straight colon cancer patients without liver metastasis(P<0.05). Diabetes mellitus, maximum tumor diameter, pathological type, degree of differentiation, depth of invasion, lymph node metastasis, pelvic peritoneum implantation,extrhepatic metastasis and smoking history were all correlated with the occurrence of liver metastasis in colorectal cancer(P<0.05). HGF,VEGF-A, diabetes, tumor maximum diameter ≥5 cm, lymph node metastasis, pelvic peritoneal implantation and extrhepatic metastasis were independent risk factors for liver metastasis of rectal cancer(P<0.05). Conclusion: The serum OPN, YKL-40, HGF and VEGF-A levels of colorectal cancer patients with liver metastasis were significantly higher than those of straight colon cancer patients without liver metastasis. HGF, VEGF-A, diabetes mellitus, tumor maximum diameter ≥5 cm, lymph node metastasis, pelvic peritoneal implantation and extrhepatic metastasis are independent risk factors for the liver metastasis of rectal cancer.

关 键 词：直结肠癌 肝转移 骨桥蛋白 人类软骨糖蛋白-39 肝细胞生长因子 血管内皮生长因子A 

分 类 号：R735.3[医药卫生—肿瘤]