金刚藤胶囊联合头孢美唑钠治疗慢性盆腔炎的临床研究  

Clinical study on Jingangteng Capsules combined with cefmetazole sodium in treatment of chronic pelvic inflammation

作　　者：袁翀英[1] 王雅丽[2] YUAN Zhong-ying;WANG Ya-li(Department of Gynecology,Zhengzhou University Hospital,Zhengzhou 450001,China;Department of Pediatrics,Henan Hospital of Traditional Chinese Medicine,Zhengzhou 450063,China)

机构地区：[1]郑州大学医院妇科,河南郑州450001 [2]河南省中医院儿科,河南郑州450063

出　　处：《现代药物与临床》2020年第8期1605-1608,共4页Drugs & Clinic

基　　金：河南省中医药科学研究专项课题(2016zy2094)。

摘　　要：目的探讨金刚藤胶囊联合注射用头孢美唑钠治疗慢性盆腔炎的临床疗效。方法选取2018年11月—2019年10月在郑州大学医院进行治疗的108例慢性盆腔炎患者为研究对象,根据用药差别分为对照组(54例)和治疗组(54例)。对照组患者静脉滴注注射用头孢美唑钠,1.0 g加入生理盐水100 mL,2次/d;治疗组患者在对照组治疗基础上口服金刚藤胶囊,2 g/次,3次/d。两组均经2周治疗后进行效果比较。比较两组的临床疗效,观察两组治疗前后中医症候积分、WHOQOL-100评分、血清学指标和子宫动脉血流动力参数的变化情况。结果治疗后,治疗组总有效率是98.15%显著高于对照组的85.19%(P<0.05)。经治疗,两组中医症候积分均较治疗前显著降低,而WHOQOL-100评分均增高(P<0.05);治疗后,治疗组中医症候积分低于对照组,而WHOQOL-100评分高于对照组(P<0.05)。经治疗,两组血清C反应蛋白(CRP)、粒细胞-巨噬细胞集落刺激因子(GM-CSF)、降钙素原(PCT)、血红素氧合酶1(HO-1)、单核细胞趋化蛋白-1(MCP-1)水平均较治疗前显著降低(P<0.05);且治疗后治疗组这些血清学指标显著低于对照组(P<0.05)。经治疗,两组子宫动脉血流搏动指数(PI)、阻力指数(RI)、收缩期峰值血流速度(PSV)均显著改善(P<0.05),且以治疗组改善更显著(P<0.05)。结论金刚藤胶囊联合注射用头孢美唑钠治疗慢性盆腔炎具有较好的临床疗效,可有效改善患者临床症状,降低机体炎症反应,有利于改善子宫动脉血流动力学指标,提高患者生活质量,具有一定的临床推广应用价值。Objective To investigate the clinical efficacy of Jingangteng CapsuleS combined with Cefmetazole Sodium for injection in treatment of chronic pelvic inflammation.Methods 108 Patients with chronic pelvic inflammation who were treated in Zhengzhou University Hospital from November 2018 to October 2019 were selected as the research objects,and they were divided into control group(54 cases)and treatment group(54 cases)according to the difference of medication.The control group was iv administered with Cefmetazole Sodium for injection,1.0 g was added to normal saline 100 mL,twice daily.The treatment group was po administered with Jingangteng Capsules on the basis of the control group,2 g/time,three times daily.The two groups were compared after 2 weeks of treatment.The clinical efficacy of the two groups was compared,and the changes of TCM syndrome score,WHOQOL-100 score,serological indexes and uterine artery hemodynamic parameters were observed before and after treatment in the two groups.Results After treatment,the total effective rate of the treatment group was 98.15%,significantly higher than that of the control group(85.19%)(P<0.05).After treatment,the scores of TCM syndromes in both groups were significantly lower than before treatment,while WHOQOL-100 score was increased(P<0.05).After treatment,the scores of TCM syndromes in the treatment group were lower than those in the control group,while the WHOQOL-100 score was higher than that in the control group(P<0.05).After treatment,the serum levels of C-reactive protein(CRP),granulocyte-macrophage colony stimulating factor(GM-CSF),procalcitonin(PCT),heme oxygenase 1(HO-1)and monocyte chemotactic protein-1(McP-1)in two groups were significantly lower than before treatment(P<0.05).After treatment,the serological indexes of the treatment group were significantly lower than those of the control group(P<0.05).After treatment,the uterine artery pulse index(PI),resistance index(RI)and systolic peak blood flow velocity(PSV)of the two groups were significantly improved(P<0.

关 键 词：金刚藤胶囊 注射用头孢美唑钠 慢性盆腔炎 中医症候积分 WHOQOL-100评分 C反应蛋白 粒细胞-巨噬细胞集落刺激因子 降钙素原 血红素氧合酶1 单核细胞趋化蛋白-1 

分 类 号：R984[医药卫生—药品]