柠檬酸钙:一种有趣的有机钙生物医用材料  

Calcium citrate: an interesting organic calcium biomedical material

作　　者：杨亚楠 李峻峰[1] 王立 刘恒全[1] 赖雪飞[2] Yang Yanan;Li Junfeng;Wang Li;Liu Hengquan;Lai Xuefei(College of Materials,Chemistry&Chemical Engineering,Chengdu University of Technology,Chengdu 610059,Sichuan Province,China;College of Chemical Engineering,Sichuan University,Chengdu 610064,Sichuan Province,China)

机构地区：[1]成都理工大学材料化学与化工学院,四川省成都市610059 [2]四川大学化学工程学院,四川省成都市610064

出　　处：《中国组织工程研究》2021年第10期1609-1615,共7页Chinese Journal of Tissue Engineering Research

摘　　要：背景:柠檬酸钙作为补钙剂、抗凝剂、抗炎剂、骨修复材料等在生物医用相关领域均有良好应用。目的:描述柠檬酸钙的基本性质,总结探讨其种制备工艺方法及在生物医用领域的主要应用。方法:通过计算机在Web of science、CNKI及Medline等数据库检索与柠檬酸钙相关的研究文献,主要的检索词有"Calcium citrate,bone repairing material,Citrate and calcium phosphate,柠檬酸钙,骨修复材料",设置发表时间为1920年2月至2020年2月。结果与结论:随着医用材料的发展和探索,因性能需求而改变原来的工艺方法以提高医用柠檬酸钙的生物活性,利用条件可控的合成制备方法得到多种微观形貌、生物活性高的柠檬酸钙是一种必然趋势。柠檬酸钙的应用较广泛,例如作为补钙剂、抗炎剂、抗凝剂、骨修复材料及在一些其他非医用领域的应用,其优点正在被研究者们慢慢发掘。制备方法对于柠檬酸钙的应用领域起决定性作用,不同的内部结构和尺寸大小都会带来不一样的应用领域,从最小的化学键连接不同到宏观的形貌或者力学性能,这些因素或许正是研究者所潜心探索的结果。BACKGROUND: Calcium citrate has been used as calcium supplement, anticoagulant, anti-inflammatory agent and bone repair material in biomedical fields. OBJECTIVE: To describe the basic properties of calcium citrate, summarize and discuss the preparation process of calcium citrate and its main applications in biomedical field. METHODS: The research literature related to calcium citrate was searched on the Web of science, CNKI, Medline and other databases by computer. The main key words were "calcium citrate, bone repairing material, citrate and calcium phosphate" in English and "calcium citrate, bone repair materials" in Chinese. The searching time was from February 1920 to February 2020.RESULTS AND CONCLUSION: With the development and exploration of medical materials, it is necessary to change the original process to improve the biological activity of medical calcium citrate. It is an inevitable trend to obtain calcium citrate with various micro-morphology and high biological activity by controllable synthesis method. Calcium citrate is widely used as calcium supplement, anti-inflammatory agent, anticoagulant, bone repair material and other non-medical applications. Its advantages are being gradually explored by researchers. The preparation method plays a decisive role in the application field of calcium citrate. Different internal structure and size will bring different application fields, from the smallest chemical bond connection to the macroscopic morphology or mechanical properties. These factors may be the results of the dedicated exploration of researchers.

关 键 词：材料 柠檬酸钙 生物材料 制备方法 补钙剂 骨修复 综述 

分 类 号：R459.9[医药卫生—治疗学] R318.08[医药卫生—临床医学]