外周血中性粒细胞CD4(nCD4)在白血病合并细菌感染患者检测中的应用价值  

Application Value of Peripheral Blood Neutrophil CD4(nCD4)in Detection of Natients with Leukemia Complicated by Bacterial Infection

作　　者：李娜[1] 张楠 袁晶 刘军辉[1] 邱瑞萍 LI Na;ZHANG Nan;YUAN Jing;LIU Jun-hui;QIU Rui-ping(Department of Laboratory Medicine,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710061,China;Department of Laboratory Medicine,Northwest Women and Children's Hospital,Xi'an,Shaanxi,710061,China)

机构地区：[1]西安交通大学第一附属医院检验科,陕西西安710061 [2]西北妇女儿童医院检验科,陕西西安710061

出　　处：《现代生物医学进展》2020年第16期3087-3090,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81500219);陕西省科学技术研究发展计划项目(2016SF-217)。

摘　　要：目的:观察外周血中性粒细胞CD4(neutrophil CD4,nCD4)在白血病合并细菌感染患者检测中的准确度和灵敏度,评价其临床应用价值。方法:筛选我院在2016年1月至2019年1月期间收治的100例白血病患者作为研究对象并纳入研究组,其中合并47例合并细菌感染者纳入研究Ⅰ组,其余53例未合并细菌感染者纳入研究Ⅱ组,另外根据血培养检查结果将研究Ⅰ组分为阳性组(n=12)和阴性组(n=35),同时,筛选同时期进行健康体检者50例纳入对照组;对比降钙素原(Procalcitonin,PCT)、C-反应蛋白(C-reactive protein,CRP)及nCD4水平,并比较阳性组和阴性组的PCT、CRP、nCD4的诊断准确度和灵敏度。结果:研究组的PCT、CRP、nCD4高于对照组(P<0.05),研究Ⅰ组的PCT、CRP、nCD4高于研究Ⅱ组(P<0.05);研究Ⅰ组中,阳性组的nCD4荧光强度高于阴性组(P<0.05);nCD4诊断白细胞细菌感染的准确度、灵敏度、特异度优于CRP及PCT诊断。结论:nCD4在白血病合并细菌感染患者检测中具有较好的临床参考价值,联合PCT、CRP检测能够显著提高检测准确性,可以作为诊断白血病合并细菌感染的诊断指标。Objective:Observe the accuracy and sensitivity of peripheral blood neutrophil CD4(nCD4)in the detection of patients with leukemia complicated by bacterial infection,and evaluate its clinical application value.Methods:100 patients with leukemia admitted in our hospital from January 2016 to January 2019 were selected as the research object and included in the study group.Among them,47 patients with bacterial infection were included in study groupⅠ,and the remaining 53 patients without bacterial infection were included.StudyⅡgroup,according to the results of blood culture examination,the studyⅠcomponents were positive group(n=12)and negative group(n=35).At the same time,50 cases of healthy physical examination at the same period were screened into the control group;The levels of PCT,CRP and nCD4 were compared,and the diagnostic accuracy and sensitivity of PCT,CRP,and nCD4 in the positive and negative groups were compared.Results:The PCT,CRP,and nCD4 in the study group were higher than those in the control group(all P<0.05),and the PCT,CRP,and nCD4 in the study groupⅠwere higher than those in the studyⅡgroup(all P<0.05).The intensity was higher than that of the negative group(P<0.05).nCD4 is better than CRP and PCT in the accuracy,sensitivity and specificity of leukocyte bacterial infection.Conclusion:nCD4 has good accuracy and sensitivity in the detection of patients with leukemia complicated by bacterial infection,and combined with PCT and CRP detection can significantly improve the detection accuracy,which can be used as a diagnostic indicator for the diagnosis of leukemia combined with bacterial infection.

关 键 词：中性粒细胞CD4(nCD4) 白血病 细菌感染 临床检测 应用价值 

分 类 号：R733.7[医药卫生—肿瘤] R446.1[医药卫生—临床医学]