单纯中药治疗干眼的临床疗效Meta分析  

Efficacy in treatment of dry eye by Traditional Chinese Medicine: a meta-analysis

作　　者：黄子杨 赵展波 周婉瑜[1] HUANG Ziyang;ZHAO Zhanbo;ZHOU Wanyu(Ophthalmology Department,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]中国中医科学院西苑医院,北京100091

出　　处：《中国中医眼科杂志》2020年第6期451-456,共6页China Journal of Chinese Ophthalmology

摘　　要：目的评价单纯应用中药治疗干眼的有效性及主要治法。方法按Cochrane系统评价方法检索数据库查找有关中药治疗干眼的随机对照试验,检索时间从建库至2019年2月。对纳入研究进行质量评价,使用RevMan5.3统计软件进行资料提取与Meta分析。结果纳入15篇文献,共包括2182眼,全部为中文文献。Meta分析结果显示,与对照组相比,单纯中药治疗干眼在延长泪膜破裂时间(BUT)[MD=2.29,95%CI(1.43,3.16),P=0.000]、增加泪液分泌量(SⅠT)[SMD=0.92,95%CI(0.45,1.39),P=0.000]及提高总体疗效方面[OR=3.29,95%CI(2.49,4.34),P=0.000]均有统计学意义(P<0.05),在改善角膜荧光染色(FL)[SMD=0.52,95%CI(-0.36,1.40),P=0.24]和干眼症状方面[SMD=0.10,95%CI(-0.68,0.89),P=0.80]无统计学意义。另外,13个研究主要治法为滋养阴液之法,其余以疏肝、清热润燥、温肾助阳为主。有2个研究干预组采用中药内服加外熏;仅有1个研究进行了泪河高度测定。结论中药治疗干眼能显著延长患者泪膜破裂时间和增加泪液分泌量,在治疗干眼总体疗效上更有优势。单纯应用中药治疗干眼时,多为滋养阴液之法。OBJECTIVE To evaluate the efficacy and main treatment of dry eye with simple application of Traditional Chinese Medicine(TCM).METHODS According to the Cochrane evaluation system method,we searched the database for the randomized controlled trials of dry eye with Traditional Chinese Medicine.The retrieval time was from the time of the database establishment to February 2019.We included randomized controlled trials conducted the TCM in the treatment of dry eye.RevMan 5.3 statistical software data extraction and Meta-analysis were conducted.RESULTS A total of fifteen studies including 2182 eyes,which were all from Chinese literature were identified.Compared with the control group,the results of meta-analysis showed that there were statistically significant differences(P<0.05)in prolonging tear breakup time(BUT)[MD=2.29,95%CI(1.43,3.16),P=0.000],increasing tear secretion[(SIT)SMD=0.92,95%CI(0.45,1.39),P=0.000]and improving the overall efficacy[OR=3.29,95%CI(2.49,4.34),P=0.000]for dry eye treated with Traditional Chinese Medicine.There were no significant statistical differences in improving cornea fluorescence staining(FL)[SMD=0.52,95%CI(-0.36,1.40),P=0.24]and dry eye symptoms[SMD=0.10,95%CI(-0.68,0.89),P=0.80].In addition,thirteen studies were mainly for the therapeutic methods of nourishing yin liquid and others mainly soothing the liver,clearing lung heat,moistening dryness and warming the kidney and assisting yang.There were two studies intervention groups using Chinese Medicine for oral and external fumigation;Only one study measured tear meniscus height.CONCLUSIONS TCM treatment of dry eye could significantly prolong BUT and increase SIT,which had more advantages in the overall effect of the treatment of dry eye.When applying TCM to treat dry eye simply,it was mostly the therapeutic method of nourishing yin liquid.

关 键 词：中药 滋阴法 干眼 META分析 随机对照试验 

分 类 号：R777.34[医药卫生—眼科]