阿尔茨海默病患者脑内tau蛋白分布与认知组分相关性的PET显像研究  

Exploring the Relationships between Cognitive Dysfunction and the Distribution of Tau Protein in the Brain of Alzheimer’s Disease Patients

作　　者：鲁佳荧 蒋皆恢[2] 王敏[2] 鲍伟奇 李明 李玲 管一晖 赵倩华 左传涛 LU Jia-ying;JIANG Jie-hui;WANG Min;BAO Wei-qi;LI Ming;LI Ling;GUAN Yi-hui;ZHAO Qian-hua;ZUO Chuan-tao(PET Center,Huashan Hospital,Fudan University,Shanghai 200235,China;Shanghai Institute for Advanced Communication and Data Science,Shanghai University,Shanghai 200044,China;Department of Neurology,Huashan Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华山医院PET中心,上海200235 [2]上海大学先进通信与数据科学研究院,上海200044 [3]复旦大学附属华山医院神经内科,上海200040

出　　处：《中国临床神经科学》2020年第4期396-404,共9页Chinese Journal of Clinical Neurosciences

基　　金：国家自然科学基金(编号:81971641,81271516,61603236);上海市科学技术委员会重点专项(编号:17411950106);国家重大慢性非传染性疾病防控专项(编号:2016YFC1306402)。

摘　　要：目的利用tau蛋白显像剂[18F]-APN-1607研究阿尔茨海默病(AD)患者脑内tau蛋白沉积的空间分布特点及其与各不同领域认知功能的相关性。方法回顾性分析23例AD患者和13例正常对照者的脑[18F]-APN-1607PET显像,采用基于感兴趣区(ROI)的标准摄取值比值(SUVR)方法比较AD组和对照组脑内tau蛋白分布差异,并利用偏相关分析探索脑内tau蛋白分布与成套神经心理测验各认知域评分之间的关系。结果与对照组比较,AD组有广泛的皮质tau蛋白沉积。记忆功能与全脑、额叶、颞叶、前扣带回、岛叶的tau蛋白分布呈显著负相关。视空间功能与枕叶、注意与额叶tau蛋白分布呈负相关趋势。语言和执行功能与各脑区的tau蛋白分布未见显著相关性。结论tau蛋白显像剂[18F]-APN-1607可有效显示AD患者脑内tau蛋白沉积,特定脑区tau蛋白负荷与特定认知损害显著相关。[18F]-APN-1607有潜力用于AD诊断;其摄取分布与认知损害临床表现密切相关。Aim To explore the utilities of[18 F]-APN-1607 tau PET tracer in quantifying the quantity and the distribution of abnormal tau proteins in brains of Alzheimer’s disease(AD)patients and understand the relationship between the signals of[18 F]-APN-1607 and cognitive dysfunction.Methods[18 F]-APN-1607 PET imaging of 23 AD and 13 normal control from Huashan Hospital,Fudan University were retrospectively analyzed.The retention of[18 F]-APN-1607 between the two groups were compared by the standardized uptake value ratio(SUVR)of the region of interest(ROI).The relationships among cognitive domain scores of a complete set of neuropsychological tests and regional tau burden were analyzed by partial correlation.Results Compared to normal control group,AD patients had widespread retention of[18 F]-APN-1607(tau burden)in cerebral cortex.Memory function was significantly negatively correlated with the distribution of abnormal tau proteins in the whole brain,frontal lobe,temporal lobe,anterior cingulate gyrus and insular lobe.Though without reaching significance,visuospatial function showed broadly similar correlation with occipital lobe,as well as attention with frontal lobe,while language and executive function were not significantly related to the distribution of tau protein.Conclusion[18 F]-APN-1607 tau tracer could effectively detect the abnormal tau protein burden in the brains of AD patients.Tau distribution in specific brain regions was significantly associated with specific cognitive dysfunctions.Our study suggests that[18 F]-APN-1607 is a potential tool for the diagnosis of AD and its distribution is closely related to the clinical manifestations of cognitive impairment.

关 键 词：阿尔茨海默病 TAU蛋白 正电子发射断层扫描 认知功能神经心理学测试 

分 类 号：R817.4[医药卫生—影像医学与核医学] R742[医药卫生—放射医学]