紧张性头痛患者甲状腺功能改变及其临床意义  

Thyroid function changes in patients with tension-type headache and its clinical value

作　　者：安媛[1] 李虓[1] 白亚秋[1] An Yuan;Li Xiao;Bai Yaqiu(Department of Neurology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070)

机构地区：[1]首都医科大学附属北京天坛医院神经内科,北京100070

出　　处：《卒中与神经疾病》2020年第4期488-490,527,共4页Stroke and Nervous Diseases

摘　　要：目的探讨紧张性头痛患者甲状腺功能改变及其临床意义。方法选择2016年1月-2019年6月本院收治的120例紧张性头痛患者作为观察组,选择同时期来本院进行体检的120名健康人作为对照组,比较2组研究对象的一般资料、匹兹堡睡眠指数PSQI评分、汉密尔顿17项抑郁评分、蒙特利尔认知功能MoCA-C评分、疼痛视觉量表VAS评分,检测2组患者血清中促甲状腺激素TSH、总甲状腺素TT4、总三碘甲状腺原氨酸TT3、游离甲状腺素FT4、游离三碘甲状腺原氨酸FT3、甲状腺球蛋白抗体TGAb、甲状腺过氧化物酶抗体TPOAb水平。结果 2组患者的年龄、性别及受教育年限均无明显差异(P>0.05),观察组PSQI评分、HAMD-17评分、TSH、TPOAb、TGAb水平均明显高于对照组(P<0.05),MoCA评分、TT3、TT4、FT3、FT4水平均明显低于对照组(P<0.05),VAS评分与PSQI评分、HAMD-17评分、TSH、TPOAb、TGAb水平呈正相关,与认知功能MoCA评分、TT3、TT4、FT3、FT4水平呈负相关。结论甲状腺功能低下及自身免疫性损伤与紧张性头痛的发生密切相关,甲状腺激素及相关抗体的检测有助于紧张性头痛的诊断及预后判定。Objective To study the changes of thyroid function in patients with tension-type headache and its clinical value. Methods 120 patients with tension-type headache admitted to our hospital from January 2016 to June 2019 were selected as the observation group, and 120 healthy people who came to our hospital for physical examination in the same period were selected as the control group. The general information, PSQI score, HAMD-17 score, MoCA score and VAS score of the two groups were compared, and TSH, TT4, TT3, FT4, FT3, TGAb and TPOAb levels in serum of the two groups were detected. Results There were no significant differences in age, gender and years of education between the two groups(P>0.05).The PSQI score, HAMD-17 score, TSH, TPOAb and TGAb levels in the observation group were significantly higher than those in the control group(P<0.05), and the MoCA score, TT3, TT4, FT3 and FT4 levels were significantly lower than those in the control group(P<0.05). VAS score was positively correlated with PSQI score, HAMD-17 score, TSH, TPOAb and TGAb levels, and negatively correlated with MoCA score, TT3, TT4, FT3 and FT4 levels. Conclusion Hypothyroidism and autoimmune injury were closely related to the occurrence of tension-type headache. The detections of thyroid hormone and related antibodies were helpful for the diagnosis and prognosis of tension-type headache.

关 键 词：紧张性头痛 甲状腺功能 临床价值 

分 类 号：R741.04[医药卫生—神经病学与精神病学]