雷帕霉素促进缺血性脑卒中后神经血管单位修复  

Rapamycin promotes repair of neurovascular units after ischemic stroke

作　　者：吴致远 邓仪昊 张永杰 何红云 WU Zhi-yuan;DENG Yi-hao;ZHANG Yong-jie;HE Hong-yun(School of Medicine,Kunming University of Science and Technology,Kunming 650500,China)

机构地区：[1]昆明理工大学医学院,云南昆明650500

出　　处：《中国病理生理杂志》2020年第9期1709-1714,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81960418,No.81860411);云南省万人计划青年拔尖人才专项(No.YNWRQNBJ-2018-034);云南省应用基础研究计划项目(No.2017FB113,No.2019FB098);云南省教育厅科研基金项目(No.2018JS016);云南省省级人培项目(No.KKSY201760028)。

摘　　要：脑卒中(cerebral stroke)是一种由脑血管病变引起的、以脑组织损伤及相应神经功能缺陷为主要临床表现的急性脑血管病,可分为缺血性和出血性2种,该病具有致残率高、死亡率高和发病率高的特点[1]。我国每年脑卒中新发病例超过200万,约有120万人死于脑卒中相关疾病,脑卒中已经成为了家庭和社会的沉重负担[2]。Neurovascular unit(NVU)is composed of neurons,endothelial cells,pericytes,astrocytes,mac rophages/microglia,smooth muscle cells,extracellular matrix,etc,and plays vital roles in maintenance of the normal brain tissue function and cellular homeostasis.Cerebral ischemia caused by stroke can harm various components of NVU.Repairing damaged NVU and maintaining its structural and functional integrity are an effective way to improve stroke treat ment.Resent research has found that rapamycin not only enhances autophagy of neurons but also effectively repairs the in juried components of NVU,thereby reducing neural damage after stroke.In this paper,the mechanisms of rapamycin un derlying the repair of injured NVU after ischemic stroke is reviewed to provide guidance for its application in the treatment of stroke.

关 键 词：缺血性脑卒中 雷帕霉素 神经血管单位 神经保护 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R363[医药卫生—临床医学]