前列腺素合酶在肝脏疾病中的作用  

Role of prostaglandin E synthases in liver diseases

作　　者：蔡杰 卢佶翃 高航 万志康 孙莹 CAI Jie;LU Jihong;GAO Hang;WAN Zhikang;SUN Ying(Department of Pharmacy,Xuzhou Medical University,Xuzhou,Jiangsu 221000,China;Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy,Xuzhou,Jiangsu 221000,China)

机构地区：[1]徐州医科大学药学院,江苏徐州221000 [2]江苏省新药研究和临床药学重点实验室,江苏徐州221000

出　　处：《临床肝胆病杂志》2020年第9期2137-2140,共4页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81603179)。

摘　　要：前列腺素E2(PGE2)是花生四烯酸产生的具有生物活性的多不饱和脂肪酸,其主要代谢器官是肝脏并对多种肝脏疾病具有重要的调控作用。前列腺素合酶(PGES)是PGE2合成途径中重要的末端限速酶,参与调控肝脏疾病的发生发展。主要总结了已有研究中各种PGES在肝损伤、肝炎和肝癌方面的作用,希望可以为进一步深入研究PGES在肝脏疾病中的作用提供参考依据。Prostaglandin E2(PGE2)is a bioactive polyunsaturated fatty acid produced by arachidonic acid,and it is mainly metabolized in the liver and has an important regulatory effect on various liver diseases.Prostaglandin E synthases(PGESs)are important terminal rate-limiting enzymes in the PGE2 synthesis pathway and are involved in the development and progression of liver disease.This article mainly summarizes the role of PGESs in liver injury,hepatitis,and liver cancer in existing studies,hoping to provide a reference for further research on the role of PGESs in liver diseases.

关 键 词：肝疾病 前列腺素E类 基因表达调控 

分 类 号：R575[医药卫生—消化系统]