康柏西普联合EX-PRESS青光眼引流器植入对NVG患者视力及并发症的影响  

Effect on vision and complications of Conbercept combined with EX-PRESS glaucoma drainage device implantation for patients with neovascular glaucoma

作　　者：赵媛[1] 余敏[1] 代艳[1] 张然[1] 李建全[1] 唐云户 Yuan Zhao;Min Yu;Yan Dai;Ran Zhang;Jian-Quan Li;Yun-Hu Tang(Department of Ophthalmology, Mianyang Central Hospital, Mianyang 621000, Sichuan Province, China)

机构地区：[1]中国四川省绵阳市中心医院眼科,621000

出　　处：《国际眼科杂志》2020年第10期1809-1813,共5页International Eye Science

基　　金：绵阳市科技计划项目(No.15S-ZC-03)。

摘　　要：目的:探讨玻璃体腔注射康柏西普联合EX-PRESS青光眼引流器植入对新生血管性青光眼(NVG)患者视力及并发症的影响。方法:选取2016-02/2018-10我院眼科收治的NVG患者128例,依据患者的治疗方法分为EX-PRESS组(n=66)和小梁切除术组(n=62),两组患者接受玻璃体腔注射康柏西普治疗,EX-PRESS组患者加行EX-PRESS青光眼引流器植入术治疗,小梁切除术组患者则加行小梁切除术治疗。比较两组手术疗效及术后眼压变化、视力改善情况及并发症发生情况。结果:术后12mo时,EX-PRESS组、小梁切除术组手术治疗总成功率分别为81.8%(54/66)、72.6%(45/62)(P>0.05);术后1、7d,1、3、6、12mo,两组患者眼压均显著低于术前(P<0.05),但两组患者眼压无差异(P>0.05);术后6mo,EX-PRESS组患者视力改善情况显著优于小梁切除术组患者(P<0.05);EX-PRESS组、小梁切除术组术后并发症总发生率分别为27.3%(18/66)、37.1%(23/62)(P>0.05)。结论:玻璃体腔注射康柏西普联合EX-PRESS青光眼引流器植入术与联合小梁切除术治疗NVG的有效性、安全性相似,而前者在改善视力方面更具优势。AIM:To investigate the effect on vision and complications of Conbercept combined with EX-PRESS glaucoma drainage device implantation for patients with neovascular glaucoma(NVG).METHODS:Totally 128 cases of patients with NVG admitted to ophthalmology in our hospital from February 2016 to October 2018 were selected and divided into EX-PRESS group(n=66)and Trabeculectomy group(n=62)according to their treatment methods.Patients in both groups received conbercept intravitreal injection,patients in EX-PRESS group were treated with EX-PRESS glaucoma drainage device implantation,and patients in Trabeculectomy group were treated with Trabeculectomy.The surgical efficacy,postoperative intraocular pressure,visual acuity improvement and complications were compared between the two groups.RESULTS:At 12mo postoperatively,the total successful rate of surgery in the EX-PRESS group and Trabeculectomy group were 81.8%(54/66)and 72.6%(45/62),respectively.There was no significant difference on the surgical efficacy between the two groups(P>0.05).At 1d,7d,1mo,3mo,6mo,12mo postoperatively,the two group were significantly lower than preoperation(P<0.05),but there was no significant difference on intraocular pressure between the two groups(P>0.05).At 6mo,12mo postoperatively,the vision improvement of EX-PRESS group was significantly better than that of Trabeculectomy group(P<0.05).The total postoperative complication rate of EX-PRESS group and Trabeculectomy group were 27.3%(18/66)and 37.1%(23/62),respectively(P>0.05).CONCLUSION:The effectiveness and safety of conbercept intravitreal injection combined with EX-PRESS glaucoma drainage device implantation is similar to combined trabeculectomy for patients with NVG,and the former is more advantageous in improving eyesight.

关 键 词：新生血管性青光眼 康柏西普 EX-PRESS青光眼引流器 视力 并发症 

分 类 号：R779.6[医药卫生—眼科]