图形翻转视觉诱发电位及扫描图形视觉诱发电位对中心性浆液性脉络膜视网膜病变视功能的评估  

Evaluation of visual function in central serous chorioretinopathy by pattern reversal visual evoked potential and sweep pattern visual evoked potential

作　　者：解瑞[1] 崔云[1] 原丽[2] 刘晓玲 Xie Rui;Cui Yun;Yuan Li;Liu Xiaoling(Department of Ophthamology,Heping Hospital Affiliated Changzhi Medical College,Changzhi 046000,China;Department of Physiology,Changzhi Medical College,Changzhi 046000,China;Department of Fundus,Eye Hospital of Wenzhou Medical University,Wenzhou 325027,China)

机构地区：[1]长治医学院附属和平医院眼科,046000 [2]长治医学院生理学教研室,046000 [3]温州医科大学附属眼视光医院眼底内科,325027

出　　处：《中华眼底病杂志》2020年第9期707-713,共7页Chinese Journal of Ocular Fundus Diseases

摘　　要：目的探讨图形翻转VEP(PRVEP)及扫描图形VEP(SPVEP)在中心性浆液性脉络膜视网膜病变(CSC)视功能评估中的应用价值。方法回顾性临床研究。2016年3月至2018年12月于长治医学院附属和平医院眼科检查确诊的单眼CSC患者38例纳入研究。其中,男性34例,女性4例;平均年龄(40.0±5.2)岁。所有患者于急性期(病程≤3个月)和临床治愈期(病程≤6个月)双眼采用德国Roland公司电生理RETIport系统行PRVEP检测,刺激图形采用1.00°和0.25°刺激视角的棋盘格,观察P100波峰幅值和峰时。SPVEP检查设备和方法同PRVEP,空间频率依次为1、2、4、6、8、12、16、22 cpd。比较SPVEP视力与主观视力的差异。患眼与对侧眼PRVEP波峰幅值、峰时及SPVEP振幅、相位比较采用配对t检验;患眼与对侧眼主观视力和SPVEP视力比较采用Wilcoxon配对秩和检验;急性期患眼主观视力与SPVEP视力行Pearson积矩相关分析。结果急性期,患眼P100波峰幅值较对侧眼降低(t=30.26、13.59),峰时延长(t=-19.89、-29.41),差异均有统计学意义(P<0.01);临床治愈期,患眼、对侧眼P100波峰幅值(t=1.49、-0.57)、峰时(t=-1.22、-1.84)比较,差异均无统计学意义(P>0.05)。急性期,不同空间频率患眼、对侧眼SPVEP振幅比较,差异均有统计学意义(P<0.01);空间频率1、2、4、6、8、12 cpd,患眼、对侧眼相位比较,差异有统计学意义(P<0.01)。临床治愈期,空间频率6、8、12、16 cpd,患眼、对侧眼SPVEP振幅比较,差异有统计学意义(P<0.01);空间频率6、8、12 cpd,患眼、对侧眼SPVEP相位比较,差异有统计学意义(P<0.01)。急性期、临床治愈期,患眼SPVEP视力均低于对侧眼,差异有统计学意义(P<0.01);急性期、临床治愈期,患眼、对侧眼SPVEP视力均低于主观视力,差异有统计学意义(急性期:Z=-5.38、-3.00,P<0.001、0.003;临床治愈期:Z=-5.36、-5.38,P<0.001、<0.001)。急性期,患眼主观视力与SPVEP视力呈正相关(r=0.847,P<0.001)。结Objective To investigate the value of pattern reversal visual evoked potential(PRVEP)and sweep pattern visual evoked potential(SPVEP)in evaluating the visual function of patients with central serous chorioretinopathy(CSC).Methods A retrospective clinical trial.A total of 38 monocular CSC patients were enrolled from March 2016 to December2018 in Heping Hospital Affiliated Changzhi Medical College.There were 34 males and 4 females with the mean age of 40.0±5.2 years.All patients undergo PRVEP detection in both the acute phase(disease course≤3 months)and the clinical cure phase(disease course≤6 months)using the German Roland electrophysiological RETIport system.The stimulation pattern adopted a checkerboard with 1.00°and 0.25°stimulation angles.The P100 peak amplitude and peak time were observed.SPVEP inspection equipment and methods were the same as PRVEP,and the spatial frequency was 1,2,4,6,8,12,16,22 cpd.The difference between SPVEP vision and subjective vision were compared.The PRVEP peak amplitude,peak time and SPVEP amplitude and phase of the affected eye and the contralateral eye were compared by paired t test;the subjective vision and SPVEP visual acuity of the affected eye and the contralateral eye were compared by Wilcoxon paired rank test;Pearson product-moment correlation analysis was performed on SPVEP vision.Results In the acute phase,the peak amplitude of P100 in the affected eye was lower than that in the contralateral eye(t=30.26,13.59),and the peak time was prolonged(t=-19.89,-29.41).The difference was statistically significant(P<0.01);in clinically cured period,the P100 peak amplitude(t=1.49,-0.57)and peak time(t=-1.22,-1.84)of the affected eye and the contralateral eye showed no significant difference(P>0.05).In the acute phase,the difference in SPVEP amplitude between the affected eye and the contralateral eye with different spatial frequencies was statistically significant(P<0.01);the phase of the affected eye and the contralateral eye were compared about the spatial frequency 1,2,4,6,8

关 键 词：中心性浆液性脉络膜视网膜病变 诱发电位 视觉 

分 类 号：R774.1[医药卫生—眼科]