ALK重排型肺癌的影像组学研究进展  

Progress of radiomics in ALK-rearranged lung cancer

作　　者：杨蕾[1] 张传玉(审校)[1] YANG Lei;ZHANG Chuanyu(Department of Radiology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院放射科,青岛266000

出　　处：《国际医学放射学杂志》2020年第5期565-568,574,共5页International Journal of Medical Radiology

摘　　要：影像组学通过提取并分析定量影像学数据,用影像特征解释基因信息,能无创显示肿瘤整体信息。应用影像组学方法探究间变性淋巴瘤激酶(ALK)基因重排与影像特征的相关性,对ALK重排型肺癌的个体化分子靶向治疗具有一定价值。阐述有关ALK重排型肺癌靶向治疗的相关知识,并对影像组学在ALK重排型肺癌的诊断及预后评估方面的研究进展进行综述。Radiomics uses the imaging features to interpret the genetic information by extracting and analyzing quantitative imaging data.It can demonstrate the overall tumor information in a non-invasive manner.Using a radiomicsbased method to explore the correlation between anaplastic lymphoma kinase(ALK)gene rearrangement and imaging features is therefore of some significance for individualized molecular targeted therapy for ALK-rearranged lung cancer.This paper presents the knowledge on targeted therapies for ALK-rearranged lung cancer,and reviews the latest advances in the application of radiomics in the diagnosis and prognosis evaluation of ALK-rearranged lung cancer.

关 键 词：肺肿瘤 间变性淋巴瘤激酶 基因重排 影像组学 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R445[医药卫生—临床医学]