“一锅法”绿色合成N1-取代的3,4-二氢嘧啶酮衍生物  

A green one-pot synthesis of N1-substituted 3,4-dihydropyrimidinones derivatives

作　　者：宋志国 赵润秋 赵爽[2] 万鑫[2] 王敏[2] SONG Zhi-Guo;ZHAO Run-Qiu;ZHAO Shuang;WAN Xin;WANG Min(Center of Experiments,Bohai University,Jinzhou 121013,China;College of Chemistry&Chemical Engineering,Bohai University,Jinzhou 121013,China)

机构地区：[1]渤海大学实验中心,辽宁锦州121013 [2]渤海大学化学化工学院,辽宁锦州121013

出　　处：《化学研究与应用》2020年第9期1731-1736,共6页Chemical Research and Application

基　　金：辽宁省自然科学基金项目(2019-MS-005)资助;辽宁省教育厅项目(LJ2019007、LQ2017010)资助;辽宁省博士启动基金(2019-BS-005)资助。

摘　　要：在80℃、无溶剂条件下,以苯磺酸钐为催化剂,芳香醛、β-酮酯、N-取代的(硫)脲三组分“一锅法”缩合,较短的反应时间内合成了产率较高的N1-取代的3,4-二氢嘧啶酮衍生物。催化剂至少能重复使用三次。产品结构经IR,1H/13 C NMR,元素分析和X-射线单晶衍射进行了确证。与已报道的合成方法相比,该方法具有原料和催化剂用量少,产率高,方法绿色等优点。The one-pot three-component condensation of aromatic aldehydes,β-ketoesters and N-substituted(thio)ureas in the presence of samarium benzenesulfonate had been accomplished under solvent-free conditions at 80℃.It afforded N1-substituted 3,4-dihydropyrimidinones derivatives with excellent yields in short reaction time.The catalyst could be reused at least three times.The structure of products was characterized by IR,1H/13 C NMR,elemental analysis and X-ray single crystal diffraction methods.Compared with the reported methods,this protocol had the advantages of small amount of raw materials and catalyst,high yield and green route,etc.

关 键 词：BIGINELLI反应 杂环化合物 一锅法 金属磺酸盐 

分 类 号：O626.4[理学—有机化学]