局部晚期乳腺癌TEC方案新辅助化疗的临床疗效分析  

Clinical efficacy of TEC regimen in neoadjuvant chemotherapy for locally advanced breast cancer

作　　者：程阳 田君[2] 姚学权 周亮[1] 刘学敏[2] 顾瑞香[2] CHENG Yang;TIAN Jun;YAO Xuequan(Department of General Surgery,Mingji Hospital Affiliated to Nanjing Medical University,Nanjing 210046,China)

机构地区：[1]南京医科大学附属明基医院普外科,江苏南京210046 [2]南京中医药大学附属张家港医院普外科,江苏张家港215600 [3]南京中医药大学附属医院肿瘤外科,江苏南京210046

出　　处：《安徽医学》2020年第9期1022-1025,共4页Anhui Medical Journal

基　　金：张家港市科技支撑计划社会发展项目(项目编号:ZKS1817)。

摘　　要：目的探讨局部晚期乳腺癌TEC方案新辅助化疗的临床疗效及安全性。方法回顾性分析2010年6月至2015年10月南京医科大学附属明基医院普外科收治的112例进展期乳腺癌患者的临床资料,根据患者的治疗方案,将接受新辅助化疗的53例患者作为治疗组,未接受新辅助化疗的59例患者作为对照组。比较两组患者肿瘤治疗有效率、不良反应发生率、术后并发症发生率、保乳率及术后复发转移率等指标的差异。结果治疗组患者治疗有效率为61.15%,对照组为3.39%,治疗组患者手术保乳率为31.19%,对照组为11.86%,差异均有统计学意义(P<0.05)。治疗组5例患者出现病情进展,两组患者术后辅助化疗不良反应、手术相关并发症等进行比较,差异无统计学意义(P>0.05)。术后随访,治疗组患者肿瘤局部复发率(22.64%)高于对照组(8.47%),差异有统计学意义(P<0.05),但远处转移率(3.77%vs 5.08%)比较,差异无统计学意义(P>0.05)。结论局部晚期乳腺癌的新辅助化疗可缩小肿瘤,增加乳腺癌患者保乳率,但增加术后局部复发率,有待进一步临床研究思考及验证。Objective To evaluate the safety and short-term efficacy of neoadjuvant chemotherapy for locally advanced breast cancer. Methods Retrospective analysis was conducted on the data of 112 cases of advanced breast cancer patients included from June 2010 to October 2015, including 53 cases of patients receiving neoadjuvant chemotherapy(treatment group) and 59 cases of patients not receiving neoadjuvant chemotherapy(control group).The effective rate of tumor treatment, the incidence of adverse reactions, the incidence of postoperative complications, the rate of breast preservation and the rate of postoperative recurrence and metastasis were compared between the two groups. Results The overall effective rate of treatment in the treatment group(61.15%) was significantly higher than that in the control group(3.39%).The breast preservation rate in the treatment group(31.19%)was significantly higher than that in the control group(11.86%), and the difference was statistically significant(P<0.05),and the progression group showed 5 cases treatment group.But there was no statistically significant difference between the two groups(P>0.05).Postoperative follow-up showed that the local recurrence rate of tumors in the treatment group(22.64%)was higher than that in the control group(8.47%), and the difference was statistically significant(P<0.05),the rate of distant metastasis was not statistically significant(3.77% vs 5.08%,P>0.05). Conclusion Neoadjuvant chemotherapy for locally advanced breast cancer can significantly reduce the tumor size and increase the breast conserving rate of breast cancer patients, but it significantly increases the local recurrence rate after surgery, which needs further clinical research and verification.

关 键 词：局部晚期乳腺癌 新辅助化疗 肿瘤复发 保乳术 

分 类 号：R737.9[医药卫生—肿瘤]