酒精性肝病的免疫微环境及其靶向药物的研究进展  

Immune microenvironment in alcoholic liver disease and advances in targeted therapy

作　　者：李煜子 王应[2] Li Yuzi;Wang Ying(Department of Rheumatology and Immunology,Peking University People′s Hospital,Beijing 100044,China;Department of Immunology,School of Basic Medical Sciences,Peking University,Beijing 100191,China)

机构地区：[1]北京大学人民医院风湿免疫科,100044 [2]北京大学基础医学院免疫学系,100191

出　　处：《中华微生物学和免疫学杂志》2020年第8期640-646,共7页Chinese Journal of Microbiology and Immunology

基　　金：国家自然科学基金(81970536)。

摘　　要：酒精性肝病是一种常见的慢性肝疾病,肝脏免疫微环境中炎性反应激活在酒精性肝病的发生、发展中有重要作用,也是酒精性肝病靶向治疗的潜在靶点。本文就酒精性肝病的病理生理机制,其免疫微环境中细胞、炎性介质成分改变及其靶向药物的研究进展作一综述。Alcoholic liver disease is a common chronic liver disease.Inflammatory pathways in the immune microenvironment of the liver play important roles in the development and progression of alcoholic liver disease,providing potential targets for therapeutic interventions.This review focused on the pathophysiology of alcoholic liver disease,changes in the immune microenvironment including immune cells and inflammatory mediators,and advances in targeted therapy.

关 键 词：酒精性肝病 免疫微环境 靶向治疗 

分 类 号：R575[医药卫生—消化系统]