全麻复合硬膜外麻醉对老年胃癌患者术后认知功能及相关蛋白表达的影响  

Observation on the Influence of General Anesthesia combined with Epidural Anesthesia for Postoperative Cognitive Dysfunction and Expression of Related Proteins of Elderly Patients with Gastric Cancer

作　　者：曹喜华[1] 徐国亭[1] 吴守宇[1] 李晓明[1] 乔泽强[1] 李海中[1] CAO Xihua;XU Guoting;WU Shouyu(First Affiliated Hospital of Nanyang Medical College,Nanyang,473058)

机构地区：[1]南阳医学高等专科学校第一附属医院,473058

出　　处：《实用癌症杂志》2020年第9期1481-1484,共4页The Practical Journal of Cancer

摘　　要：目的观察全麻复合硬膜外麻醉对老年胃癌患者术后认知功能及相关蛋白表达的影响。方法选取70例老年胃癌手术患者为研究对象,根据麻醉方式的不同分为对照组(全麻组)35例和观察组(全麻复合硬膜外麻醉组)35例。比较2组术后不同时间的认知障碍发生率、手术前后的相关蛋白(Tau蛋白、磷酸化Tau蛋白、Aβ1-40蛋白、Aβ1-42蛋白及S100B蛋白)表达情况。结果观察组术后不同时间的认知障碍发生率均低于对照组,差异有统计学意义(P<0.05)。术前2组的血清Tau蛋白、磷酸化Tau蛋白、Aβ1-40蛋白、Aβ1-42蛋白及S100B蛋白水平比较,差异均无统计学意义(P>0.05);术后观察组的血清Tau蛋白、磷酸化Tau蛋白、Aβ1-40蛋白、Aβ1-42蛋白及S100B蛋白水平均低于对照组,差异有统计学意义(P<0.05)。结论全麻复合硬膜外麻醉对老年胃癌患者术后认知功能及相关蛋白表达的影响均相对更小,在老年胃癌手术患者中的应用价值更高。Objective To observe the influence of general anesthesia combined with epidural anesthesia for postoperative cognitive dysfunction and expression of related proteins of elderly patients with gastric cancer.Methods 70 elderly gastric cancer patients treated with surgery were chosen as the research object,and they were divided into the control group(general anesthesia group)35 cases and the observation group(general anesthesia combined with epidural anesthesia group)35 cases according to the difference of anesthesia methods.Then the cognitive dysfunction rates at different time after the surgery,related proteins(Tau protein,phosphorylated Tau protein,Aβ1-40 protein,Aβ1-42 protein and S100B protein)before and after the surgery of the 2 groups were compared.Results The cognitive dysfunction rates of the observation group at different time after the surgery were all lower than those of the control group,there were statistically significant differences(P<0.05),the serum Tau protein,phosphorylated Tau protein,Aβ1-40 protein,Aβ1-42 protein and S100B protein of the 2 groups before the surgery were compared,there were no statistically significant differences(P>0.05),the serum Tau protein,phosphorylated Tau protein,Aβ1-40 protein,Aβ1-42 protein and S100B protein of observation group after the surgery were all lower than those of control group,there were no statistically significant differences(P<0.05).Conclusion The influence of general anesthesia combined with epidural anesthesia for postoperative cognitive dysfunction and expression of related proteins of elderly patients with gastric cancer are relatively better,and its application value in the elderly surgical patients with gastric cancer is higher.

关 键 词：全麻复合硬膜外麻醉 老年胃癌手术患者 术后认知障碍 相关蛋白 

分 类 号：R735.2[医药卫生—肿瘤]