胃癌CT征象及血管生成相关因子及抑癌基因表达的相关因素分析  

Correlation between CT Signs and Angiogenesis-related Factors and Tumor Suppressor Gene Expression in Patients with Gastric Cancer

作　　者：谭华伟 Tan Huawei(Pingdingshan First People's Hospital,Pingdingshan,467000)

机构地区：[1]河南省平顶山市第一人民医院,467000

出　　处：《实用癌症杂志》2020年第9期1485-1488,共4页The Practical Journal of Cancer

摘　　要：目的观察胃癌患者CT征象,及影响胃癌患者癌组织血管生成相关因子及抑癌基因表达的因素。方法选取接受治疗的100例胃癌患者为研究对象,观察胃癌患者的CT征象、癌组织和癌旁组织血管生成相关因子及抑癌基因阳性表达的差异,分析影响胃癌患者癌组织血管生成相关因子及抑癌基因表达的因素。结果胃癌患者经CT检查效果良好,通过CT可明显鉴别患者的病理特征:T3期患者病灶浆膜面光整,周围脂肪间隙清晰;T4期患者病灶浆膜面毛躁,局部外突表现,周围脂肪间隙密度增高,部分条索状改变;癌组织中VEGF阳性率高于癌旁组织,endostatin阳性率低于癌旁组织,差异有统计学意义(χ2=106.676、144.862,P<0.001);有淋巴结转移、临床分期为Ⅳ期、肿瘤直径≥5 cm、CT最大径线≥55 mm的胃癌患者VEGF阳性率较高,有淋巴结转移、肿瘤直径≥5 cm、CT最大径线≥55 mm的胃癌患者endostatin阳性率较低;将单因素分析有意义的因素作为因变量,将胃癌患者血管生成相关因子及抑癌基因阳性表达作为自变量进行回归分析,结果显示:淋巴结转移、CT最大径线是影响胃癌患者血管生成相关因子及抑癌基因阳性表达的因素。结论胃癌患者癌组织血管生成相关因子阳性表达率较高,抑癌基因阳性表达率较低,且与患者CT最大径线和有无淋巴结转移相关。Objective To observe the CT signs of gastric cancer patients and the factors affecting the expression of angiogenesis-related factors and tumor suppressor genes in gastric cancer patients.Methods The patients with gastric cancer who were treated were enrolled.The differences of CT signs,cancer tissues and adjacent tissues of angiogenesis and tumor suppressor gene expression in gastric cancer patients were observed.Factors affecting the expression of angiogenesis-related factors and tumor suppressor genes in cancer patients.Results The CT examination of gastric cancer patients was effective.The pathological features of patients were clearly identified by CT:the lesions in the T3 stage were smooth and the peripheral fat gap was clear.In the T4 stage,the serosal facial edema,local exudation,peripheral fat The gap density increased and some of the strips changed.The positive rate of VEGF in cancer tissues was higher than that in adjacent tissues.The positive rate of endostatin was lower than that in adjacent tissues.The difference was statistically significant(χ2 value=106.676,144.862,P<0.001);Lymph node metastasis,clinical stage IV,tumor diameter≥5cm,CT maximum diameter≥55mm,gastric cancer patients with high VEGF positive rate,lymph node metastasis,tumor diameter≥5cm,CT maximum diameter≥55mm gastric cancer patients with endostatin positive rate Low;univariate analysis of meaningful factors as a dependent variable,gastric cancer patients with angiogenesis-related factors and tumor suppressor gene positive expression as an independent variable regression analysis,the results show that lymph node metastasis,CT maximum diameter is affecting gastric cancer patients angiogenesis Factors related to the positive expression of related factors and tumor suppressor genes.Conclusion The positive expression rate of angiogenesis-related factors in gastric cancer patients is higher,and the positive expression rate of tumor suppressor gene is lower,which is related to CT maximum diameter and lymph node metastasis.

关 键 词：胃癌 CT 血管生成相关因子 抑癌基因 

分 类 号：R735.2[医药卫生—肿瘤]