氟尿嘧啶植入剂在原发性肝癌切除术中的临床应用效果  

Clinical Effect of Implantation of Sustained-release 5-fluorouracil in Primary Liver Cancer

作　　者：何芳 曾彩雯 HE Fang;ZENG Caiwen(Jiangxi Cancer Hospital,Nanchang,330029)

机构地区：[1]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2020年第9期1512-1515,1519,共5页The Practical Journal of Cancer

基　　金：江西省卫生计生委科技计划项目(编号:20171852)。

摘　　要：目的探讨氟尿嘧啶植入剂在原发性肝癌切除术中使用的临床疗效。方法选取原发性肝癌患者86例。对照组患者44例单纯接受肝癌肿瘤切除术,观察组患者42例联合术中氟尿嘧啶植入剂治疗,比较2组患者治疗前后肿瘤病灶、血清学相关指标、免疫功能及复发转移率的变化情况。结果观察组患者术中使用氟尿嘧啶植入剂治疗后,CR及PR显著高于对照组患者(33.33%vs 18.18%,47.62%vs 27.27%,P均<0.05),血清AFP水平均明显低于对照组患者(P<0.05),CD4+、CD4+/CD8+水平均高于对照组(P<0.05),术后12个月及24个月肿瘤复发转移率明显低于对照组(P<0.05)。结论氟尿嘧啶植入剂在肝癌切除术术中使用可有效降低原发性肝癌患者肿瘤病灶的复发转移率,提高治疗效果,延长肿瘤患者的生存期。Objective To explore the clinical efficacy of intraoperative fluorouracil implants for primary liver cancer.Methods 86 patients with primary liver cancer underwent operations were randomly divided into the control group(42 cases,without chemotherapy)and the observation group(44 cases,intraoperative implantation of sustained-release 5-fluorouracil).The clinical data of the 2 groups was compared including changes in tumor lesions,serologically relevant indicators,immune function,and recurrence and metastasis rate.Results In the observation group,CR and PR were significantly higher than those of the control group(33.33%vs 18.18%,47.62%vs 27.27%,P<0.05),The serum AFP level was significantly lower than in the control group(P<0.05),The CD4+and CD4+/CD8+levels were higher than those of the control group,while the CD8+level was lower(P<0.05),Recurrence and metastasis rate in 12 month and 24 month of the observation group were significantly lower than the control group(P<0.05).Conclusion Intraoperative fluorouracil implants can improve clinical efficacy and reduce the recurrence metastasis rates,prolong the survival of patients.

关 键 词：氟尿嘧啶植入剂 原发性肝癌 临床疗效 

分 类 号：R735.7[医药卫生—肿瘤]