周剂量伊立替康联合顺铂一线药物治疗广泛期小细胞肺癌患者的疗效及不良反应研究  

Efficacy and side effects of weekly dose irinotecan combined with cisplatin in the first-line treatment of extensive small cell lung cancer

作　　者：黄晓鹏[1] HUANG Xiaopeng(Department of Internal Medicine-Oncology,Jiyuan Tumor Hospital,Jiyuan,Henan 459000,China)

机构地区：[1]济源市肿瘤医院肿瘤内科,河南济源459000

出　　处：《中国医学工程》2020年第9期81-83,共3页China Medical Engineering

摘　　要：目的探讨周剂量伊立替康联合顺铂一线药物治疗广泛期小细胞肺癌患者的疗效及不良反应情况。方法选取2018年2月至2019年2月在济源市肿瘤医院治疗的90例广泛期小细胞肺癌患者作为研究对象,采用随机数字表法分为研究组和对照组,每组45例。研究组予以周剂量伊立替康联合顺铂治疗;对照组予以依托泊苷联合顺铂治疗。比较两组治疗前后生活质量综合评定问卷(GQOLI-74)评分和临床疗效、不良反应发生情况。结果两组治疗前GQOLI-74评分比较,差异无统计学意义(P>0.05)。研究组治疗后GQOLI-74评分和治疗总有效率高于对照组(P<0.05)。研究组治疗后粒细胞减少、血小板减少及贫血等不良反应率低于对照组,而恶心呕吐Ⅲ~Ⅳ度不良反应率高于对照组(P<0.05)。结论采用周剂量伊立替康联合顺铂一线药物治疗广泛期小细胞肺癌患者,能够有效降低不良反应发生率,提高患者的生活质量,其临床疗效更好。【Objective】 To investigate the efficacy and side effects of weekly dose of irinotecan combined with cisplatin in the first-line treatment of extensive small cell lung cancer. 【Methods】 Ninety patients with extensive small cell lung cancer treated in our hospital from February 2018 to February 2019 were randomly divided into two groups of 45 cases each. The control group was treated with etoposide and cisplatin. The study group was treated with weekly dose of irinotecan combined with cisplatin. The scores of GQOLI-74, clinical effects and adverse reactions of the two groups were compared before and after treatment. 【Results】 Before treatment, there was no statistical difference in GQOLI-74 scores between the two groups of patients(P>0.05);after treatment, the GQOLI-74 score and total effective rate of treatment in the study group were higher than those in the control group(P<0.05). In the study group, the rates of adverse reactions such as granulocytopenia, thrombocytopenia, and anemia were lower while the incidence of Ⅲ to Ⅳ degrees of nausea and vomiting was higher than those in the control group(P<0.05). 【Conclusion】 Weekly dose of irinotecan combined with cisplatin in the first-line treatment of patients with extensive stage small cell lung cancer can effectively reduce the incidence of adverse reactions, improve the quality of life of patients, and have better clinical efficacy.

关 键 词：小细胞肺癌 药物筛选试验 抗肿瘤 治疗结果 疗效比较研究 

分 类 号：R734.2[医药卫生—肿瘤]