肿瘤微环境中肿瘤相关巨噬细胞与上皮间质化“对话”的研究进展  

The crosstalk between tumor-associated macrophage and epithelial-mesenchymal transition

作　　者：张帆[1] 郭咸希[1] Zhang Fan;Guo Xianxi(Department of Pharmacy,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China)

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060

出　　处：《现代肿瘤医学》2020年第20期3640-3646,共7页Journal of Modern Oncology

基　　金：国家自然科学基金青年基金资助项目(编号:81702819)。

摘　　要：肿瘤微环境决定了许多癌症的发生和发展。肿瘤相关巨噬细胞是肿瘤微环境中协调炎症和癌症之间的关键因子。上皮间质化的激活通常需要肿瘤细胞与局部肿瘤微环境组分(包括肿瘤相关巨噬细胞)之间的"对话"。在本篇综述中,临床和实验证据证明肿瘤相关巨噬细胞促进肿瘤侵袭和转移以及它在肿瘤转移级联反应中与上皮间质化的相互作用。此外,本文总结了以介入肿瘤相关巨噬细胞和上皮间质化的肿瘤细胞"对话"的信号通路作为肿瘤转移治疗的潜在靶点的治疗策略。The tumor microenvironment determines development and progression of many cancers.Tumor-associated macrophages(TAMs) are key cells of the tumor microenvironment that orchestrate the connection between inflammation and cancer.Activation of epithelial-mesenchymal transition(EMT) often requires crosstalk between cancer cells and components of the local tumor microenvironment,including TAMs.In this review,clinical and experimental evidence is presented for control of TAMs in promoting cancer cell invasion and migration and their interaction with the EMT process in the metastatic cascade.The translational significance of these findings is that the signaling pathways that interconnect TAMs and EMT-modified cancer cells may represent promising therapeutic targets for the treatment of tumor metastasis.

关 键 词：肿瘤微环境 肿瘤相关巨噬细胞 上皮间质化 对话 免疫治疗 

分 类 号：R730.51[医药卫生—肿瘤]