口腔细菌影响宿主表观遗传调控的研究进展  

Advances in oral bacteria influencing host epigenetic regulation

作　　者：梅宏翔 陈奕霖 施培磊 杨偲睿 徐欣[1] 何金枝[1] Mei Hongxiang;Chen Yilin;Shi Peilei;Yang Sirui;Xu Xin;He Jinzhi(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Cariology and Endodontics,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院牙体牙髓病科,成都610041

出　　处：《华西口腔医学杂志》2020年第5期583-588,共6页West China Journal of Stomatology

基　　金：国家自然科学基金青年科学基金(81600874);国家自然科学基金面上项目(81771099,81670978);四川大学大学生创新创业训练计划(C2018103959);四川省科技厅应用基础研究计划(2020YJ0240)。

摘　　要：表观遗传是指非基因序列改变所导致的基因表达水平的稳定改变,微生物能通过表观遗传途径调节宿主炎症,从而逃避或者扩大免疫反应。口腔细菌作为人体微生物的重要组成部分,目前已发现多种表观遗传调控机制可影响宿主对口腔细菌的反应。本文就细菌调控表观遗传的常见途径以及不同疾病中口腔细菌对宿主表观遗传的调控进行综述,以期为口腔疾病中表观遗传相关机制研究提供参考。Epigenetics refers to a steady change in the level of gene expression caused by non-DNA sequence changes.Microbes can modulate host inflammation through epigenetic pathways to evade or expend immune responses.As an important part of human microbes,oral bacteria also have various epigenetic regulation mechanisms to affect host inflammatory responses.This article reviews the common pathways of epigenetic regulation in microbe infection and the regulation of host epigenetics by using oral microbes to provide a reference for the study of epigenetic-related mechanisms in oral diseases.

关 键 词：口腔细菌 表观遗传 组蛋白修饰 DNA甲基化 非编码RNA 

分 类 号：R780.2[医药卫生—口腔医学]