北方汉族和蒙古族人群中运动能力差异相关基因ACTN3多态性研究  

Study on ACTN3 gene polymorphism related to the difference of athletic ability in Northern HanZú and MongguZú population

作　　者：吴剑[1] 高玉雪 杨鹏翔 郭向华 WU Jian;GAO Yuxue;YANG Pengxiang;GUO Xianghua(College of Sports Science and Health,Capital University of Physical Education and Sports,Beijing100191,China;Beijing Institute of HepatologyBeijing You′an Hospital,Capital Medical University,Beijing100069,China;Qingdao University Medical College,Shandong Province,Qingdao266071,China)

机构地区：[1]首都体育学院运动科学与健康学院,北京100191 [2]首都医科大学附属北京佑安医院北京市肝病研究所,北京100069 [3]青岛大学医学院,山东青岛266071

出　　处：《中国医药导报》2020年第25期38-41,共4页China Medical Herald

基　　金：国家自然科学基金青年科学基金项目(81601871)。

摘　　要：目的调查北方汉族与蒙古族人群α-辅肌动蛋白3(ACTN3)基因R577X多态性频率分布特征。方法2019年9-11月选择在北京佑安医院参与健康体检的北方汉族人群85名和包头医学院蒙古族2019级预科班的健康体检人群58名作为研究对象。用高通量荧光实时定量聚合酶链式反应分析不同种族、性别ACTN3基因R577X多态性。结果3种基因型在不同组人群中均符合Hardy-Weinberg平衡。北方汉族基因型频率(RR)、等位基因频率(R)高于蒙古族人群,差异有统计学意义(P<0.05)。北方汉族、蒙古族人群不同性别ACTN3基因R577X基因型分布比较,差异无统计学意义(P>0.05)。北方汉族与蒙古族不同性别的不同基因型频率、等位基因频率比较,差异无统计学意义(P>0.05)。结论北方汉族与蒙古族人群ACTN3基因R577X基因型频率和等位基因频率差异与性别无关,与爆发力相关的RR基因型频率在北方汉族人群中较高,反映耐力的XX基因型频率在蒙古族人群中较高。Objective To investigate the frequency distribution characteristics of α-actinin 3(ACTN3) gene R577X polymorphism in northern HanZú and MongguZú populations. Methods From September to November 2019, a total of85 northern HanZú people who participated in the health checkup at Beijing You’an Hospital and a total of 58 health checkup population from the 2019 preparatory class of MongguZú in Baotou Medical College were selected as the research objects. High-throughput fluorescence real-time quantitative polymerase chain reaction was used to analyze the R577X polymorphism of ACTN3 gene of different races and genders. Results The three genotypes were in accordance with Hardy-Weinberg equilibrium in different groups of people. The genotype frequency(RR) and allele frequency(R)of the northern HanZú population were higher than those of the MengguZú population, and the differences were statistically significant(P < 0.05). There was no statistically significant difference in the distribution of ACTN3 gene R577 X genotypes between different genders of northern HanZú and MongguZú(P > 0.05). The differences in different genotype frequencies, and different allele frequencies were no statically signifrcant between the northern HanZú and the MongguZú in different genders(P > 0.05). Conclusion The differences in ACTN3 gene R577X genotype frequency and allele frequency between northern HanZú and MongguZú populations have nothing to do with gender. RR genotype frequency related to explosive power is higher in northern HanZú population, while XX genotype frequency reflecting endurance in MongguZú population is higher.

关 键 词：α-辅肌动蛋白3 多态性 基因 北方汉族人群 蒙古族人群 

分 类 号：R394.112[医药卫生—医学遗传学]