CT全肿瘤灌注参数值与肝细胞癌病理分级、微血管侵犯的关系  

The relationship between CT perfusion parameters and pathological grade microvascular invasion of hepatocellular carcinoma

作　　者：李堃[1] 何海林[1] LI Kun;HE Hai-lin(Department of Medical Imaging,Baoji Central Hospital,Shanxi 721000,China)

机构地区：[1]宝鸡市中心医院医学影像科,陕西721000

出　　处：《肝脏》2020年第8期828-830,共3页Chinese Hepatology

摘　　要：目的研究CT全肿瘤灌注参数值与肝细胞癌(HCC)病理分级、微血管侵犯的关系。方法回顾性分析2017年3月至2019年3月170例HCC患者临床资料,所有患者均接受CT灌注成像检查,记录平均通过时间(MTT)、肝动脉灌注量(HAP)及肝动脉灌注指数(HAPI),并分析其与HCC病理分级和微血管侵犯的关系。结果不同分化程度HCC患者MTT、HAP及HAPI比较,差异均有统计学意义(P<0.05)。微血管侵犯组MTT较无微血管侵犯组显著缩短,HAP和HAPI显著高于无微血管侵犯组,差异均有统计学意义(P<0.05)。ROC分析结果显示MTT、HAP、HAPI判断肿瘤低分化具有较高应用价值(P<0.05)。结论CT全肿瘤灌注MTT、HAP、HAPI参数与微血管侵犯密切相关,有助于评估肿瘤病理分化程度。Objective To study the relationship between computed tomography(CT)perfusion parameters and pathological grade,microvascular invasion of hepatocellular carcinoma(HCC).Methods The clinical data of 170 patients with HCC undergoing CT perfusion imaging from March 2017 to March 2019 were retrospectively analyzed.The mean transit time(MTT),hepatic artery perfusion(HAP)and hepatic artery perfusion index(HAPI)were recorded.The relationship between perfusion parameters and HCC pathological grade,microvascular invasion was analyzed.Results There were significant differences in MTT,HAP and HAPI among HCC patients of different pathological degrees(P<0.05).MTT in microvascular invasion group was significantly shorter than that in non-microvascular invasion group(P<0.05).HAP and HAPI in microvascular invasion group were significantly higher than those in non-microvascular invasion group.(P<0.05).The receiver operator characteristic curve showed that MTT,HAP and HAPI had high application value in the diagnosis of poorly differentiated HCC(P<0.05).Conclusion MTT,HAP and HAPI of CT perfusion imaging are closely related to microvascular invasion,which are helpful to identify poorly differentiated HCC from HCC of other pathological degrees.

关 键 词：肝细胞癌 CT灌注参数 病理分级 微血管侵犯 

分 类 号：R73[医药卫生—肿瘤]