ω-3多不饱和脂肪酸对皮肤肿瘤的作用及机制研究进展  

Research Advances on Omega-3 Polyunsaturated Fatty Acids in Cutaneous Carcinoma and Molecular Mechanisms

作　　者：薛欢 王佩茹 王秀丽[2] XUE Huan;WANG Peiru;WANG Xiuli(Shanghai Skin Disease Clinical College of Anhui Medical University,Shanghai 200443,China;Institute of Photomedicine,Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China)

机构地区：[1]安徽医科大学上海皮肤病临床学院,上海200443 [2]同济大学医学院光医学研究所,上海市皮肤病医院,上海200443

出　　处：《中国皮肤性病学杂志》2020年第10期1201-1204,共4页The Chinese Journal of Dermatovenereology

基　　金：国家自然科学基金(81872512,81872212);上海市卫生计生系统优青计划(2017YQ066);上海市卫计委重点课题(201640016)。

摘　　要：长期紫外线照射、慢性炎症、机体免疫紊乱状态等是皮肤肿瘤发生发展的重要机制。ω-3多不饱和脂肪酸(ω-3 PUFAs)是人体必需脂肪酸,可以通过调控磷脂酶A2活性、抑制环氧合酶及前列腺素的产生,而减轻皮肤炎症反应及缓解免疫抑制状态;并且可增强皮肤对紫外线的抵抗力,减弱紫外线导致的DNA损伤,对皮肤肿瘤具有一定的抑制作用。本综述总结了有关ω-3 PUFAs对皮肤肿瘤的影响及其相关机制。Long-term ultraviolet radiation,chronic inflammation and immune dysfunction are important mechanisms for the development of cutaneous carcinoma.Omega-3 polyunsaturated fatty acids(ω-3 PUFAs)are essential fatty acids.It can regulate the activity of phospholipase A2 and inhibit the production of COX2 and PGE2,thus alleviating the skin inflammation and immunosuppressive state.Besides,ω-3 PUFAs can also enhance the skin's resistance to ultraviolet radiation and weaken the DNA damage caused by ultraviolet radiation.In conclusion,ω-3 PUFAs have certain preventive effects on tumors.This review summarized the effects and molecular mechanisms ofω-3 PUFAs on cutaneous carcinoma.

关 键 词：Ω-3多不饱和脂肪酸 皮肤肿瘤 免疫抑制 慢性炎症 

分 类 号：R739.5[医药卫生—肿瘤]