乳腺癌超声SWE技术分析及其与ER、PR、Ki-67表达和分子分型的相关性  

Breast cancer ultrasound SWE technical analysis and its correlation with ER,PR,Ki-67 expression and molecular typing

作　　者：王燕 方开峰[1] 俞秋雨 宋瑞[2] WANG Yan;FANG Kaifeng;YU Qiuyu;SONG Rui(Department of Ultrasound,Wanbei Coal and Electricity Group General Hospital,Anhui Province,Suzhou234000,China;Department of Pathology,Wanbei Coal and Electricity Group General Hospital,Anhui Province,Suzhou234000,China)

机构地区：[1]安徽省宿州市皖北煤电集团总医院超声科,安徽宿州234000 [2]安徽省宿州市皖北煤电集团总医院病理科,安徽宿州234000

出　　处：《中国医药导报》2020年第26期21-25,共5页China Medical Herald

基　　金：蚌埠医学院科研课题(BYZX201601)。

摘　　要：目的探讨乳腺癌超声剪切波弹性成像(SWE)技术分析结果及其与雌激素受体(ER)、孕激素受体(PR)、Ki-67抗原表达和分子分型的相关性。方法选取2017年6月—2019年10月安徽省宿州市皖北煤电集团总医院收治的100例经病理证实的乳腺癌患者作为研究对象。在对患者进行治疗前先行常规检查与SWE检查,以获取患者病灶SWE技术分析结果。术后对所有患者的肿块组织分级、雌激素受体(ER)、孕激素受体(PR)、Ki-67抗原表达水平和分子分型进行观察记录,分析研究术前SWE技术分析结果与术后患者ER、PR、Ki-67抗原表达水平和分子分型的相关性。结果肿块大小、Ki-67抗原表达、组织分级与弹性最大值平方根[Sqrt(Emax)]、弹性最大值平方根[Sqrt(Emean)]和弹性比对数[Log(Eratio)]比较,差异有统计学意义(P<0.05)。而ER表达、PR表达、人表皮生长因子受体-2(HER-2)表达及分子分型与Sqrt(Emax)、Sqrt(Emean)和Log(Eratio)比较,差异无统计学意义(P>0.05)。肿块大小、Ki-67抗原高表达与Sqrt(Emax)、Sqrt(Emean)存在相关性(P<0.05),但与Log(Eratio)无相关性(P>0.05);肿瘤组织分级情况与Sqrt(Emax)、Sqrt(Emean)、Log(Eratio)无相关性(P>0.05)。结论SWE弹性参数能在一定程度上反映患者乳腺癌的生物学特征,且肿块越大,SWE弹性值越高,Ki-67抗原表达程度越高。Objective To explore the analysis results of breast cancer ultrasound shear wave elastography(SWE)technical analysis and its correlation with estrogen receptor(ER),progesterone receptor(PR),Ki-67 antigen expression and molecular typing.Methods From June 2017 and October 2019,100 patients with pathologically confirmed breast cancer who admitted in Wanbei Coal and Electricity Group General Hospital of Anhui Province were selected as research objects.Before the treatment,routine examination and SWE examination were performed in order to obtain the results of SWE technical analysis of the patients′lesions.Postoperatively,the tumor tissue grade,ER,PR,Ki-67 antigen expression level and molecular typing of all patients were observed and recorded,and the correlation between the results of SWE technical analysis before operation and the expression levels of ER,PR,Ki-67 antigen and molecular typing in postoperative patients were analyzed.Results The differences of tumor size,Ki-67 antigen expression,tissue grade and elastic maximum square root[Sqrt(Emax)],elastic maximum square root[Sqrt(Emean)]and elastic ratio number[Log(Eratio)]were statistically significant(P<0.05).However,there were no significant differences between ER expression level,PR expression level,Human epidermal growth factor receptor-2(HER-2)expression level,molecular typing and Sqrt(Emax),Sqrt(Emean),Log(Eratio)(P>0.05).The tumor size and Ki-67 antigen expression were correlated with Sqrt(Emax)and Sqrt(Emean)(P<0.05),but not with Log(Eratio)(P>0.05).There were no correlation between tumor tissue grade and Sqrt(Emax),Sqrt(Emean)and Log(Eratio)(P>0.05).Conclusion SWE elasticity parameter can reflect the biological characteristics of breast cancer to a certain extent.The larger the mass,the higher the SWE elasticity value,and the higher the expression of Ki-67.

关 键 词：乳腺癌 超声多普勒 剪切波弹性成像 雌激素受体 孕激素受体 Ki-67 分子分型 

分 类 号：R737.9[医药卫生—肿瘤]