研究铝碳酸镁联合艾司奥美拉唑治疗胃溃疡对其黏膜组织及微血管形态的影响  

Study the effect of hydrotalcite combined with esomeprazole on mucosal tissue and microvascular morphology in patients with gastric ulcer

作　　者：姚海蓉 YAO Hai-rong(Qidong People’s Hospital(Nantong University Affiliated Qidong Hospital),Qidong 226200,China)

机构地区：[1]启东市人民医院(南通大学附属启东医院),226200

出　　处：《中国实用医药》2020年第26期102-104,共3页China Practical Medicine

摘　　要：目的研究胃溃疡患者应用铝碳酸镁联合艾司奥美拉唑治疗的临床效果及对黏膜组织及微血管形态的影响。方法100例胃溃疡患者,随机分为对照组和试验组,各50例。对照组采用铝碳酸镁治疗,试验组采用铝碳酸镁联合艾司奥美拉唑治疗。对比两组患者的临床疗效、微血管形态规则情况及临床指标[白细胞介素-8(IL-8)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)、胶原纤维沉积面积、溃疡直径]。结果试验组总有效率98.00%高于对照组的86.00%,差异有统计学意义(P<0.05)。试验组微血管形态规则率84.00%高于对照组的64.00%,差异有统计学意义(P<0.05)。治疗后,试验组IL-10(27.02±1.25)ng/L、IL-8(14.42±1.31)ng/L、TNF-α(24.71±1.28)ng/L均低于对照组的(33.52±3.25)、(27.42±1.41)、(28.61±1.35)ng/L,胶原纤维沉积面积(104296.51±304.25)mm2、溃疡直径(3.42±1.05)mm均优于对照组的(84856.52±303.16)mm2、(6.15±1.54)mm,差异有统计学意义(P<0.05)。结论胃溃疡患者采用铝碳酸镁联合艾司奥美拉唑治疗的效果显著,可有效改善机体胶原纤维沉积面积及微血管形态。Objective To study the clinical effect of hydrotalcite combined with esomeprazole in patients with gastric ulcer and its influence on mucosal tissue and microvascular morphology.Methods A total of 100 cases of patients with gastric ulcer were randomly divided into control group and experimental group,with 50 cases in each group.The control group was treated with hydrotalcite,and the experimental group was treated with hydrotalcite combined with esomeprazole.The clinical efficacy,microvascular morphology and clinical indicators[interleukin-8(IL-8),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),collagen fiber deposition area,ulcer diameter]was compared between the two groups.Results The total effective rate 98.00%of the experimental group was higher than that of the control group 86.00%,and the difference was statistically significant(P<0.05).The regular rate of microvascular morphology 84.00%of the experimental group was higher than that of the control group 64.00%,and the difference was statistically significant(P<0.05).After treatment,IL-10(27.02±1.25)ng/L,IL-8(14.42±1.31)ng/L and TNF-α(24.71±1.28)ng/L of the experimental group was lower than that of the control group(33.52±3.25),(27.42±1.41)and(28.61±1.35)ng/L,and collagen fiber deposition area(104296.51±304.25)mm2 and ulcer diameter(3.42±1.05)mm was better than that of the control group(84856.52±303.16)mm2 and(6.15±1.54)mm,and the difference was statistically significant(P<0.05).Conclusion Hydrotalcite combined with esomeprazole shows remarkable effect on patients with gastric ulcer,which can effectively improve the collagen fiber deposition area and the microvascular morphology.

关 键 词：铝碳酸镁 艾司奥美拉唑 胃溃疡 黏膜组织 微血管形态 

分 类 号：R573.1[医药卫生—消化系统]