青少年肌阵挛癫痫发作过程脑电信号子波熵分析  

A wavelet entropy analysis of ictal electroencephalogram signals of juvenile myoclonic epilepsy

作　　者：王玉玲 张贝贝 王静[2] 张美云[2] 陈英[3] 王凤楼[3] WANG Yu-Ling;ZHANG Bei-Bei;WANG Jing;ZHANG Mei-Yun;CHEN Ying;WANG Feng-Lou(Graduate School,Tianjin Medical University,Tianjin 300070,China;Department of Neurology,Tianjin Union Medical Center,Tianjin 300121,China;De-partment of Neurology,General Hospital of Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津市人民医院神经内科,天津300121 [3]天津医科大学总医院神经内科,天津300052

出　　处：《国际神经病学神经外科学杂志》2020年第4期343-352,共10页Journal of International Neurology and Neurosurgery

基　　金：天津市自然科学基金项目(14JCYBJC27000)。

摘　　要：目的采用子波熵研究青少年肌阵挛癫痫(JME)发作过程的动态变化,探索其发作的动力学机制,为监测癫痫发作提供更好的指标。方法采用Gauss连续子波变换对10例JME患者(JME组)癫痫发作的脑电信号进行分解,在此基础上行子波功率谱分析,并计算整体子波熵(En)和分尺度子波熵[En(a)],根据视觉脑电结果将熵值分为发作间期、发作前期和发作期,观察JME发作全过程子波熵值的动态变化,总结其变化规律并与正常对照组比较。结果JME组发作期整体子波熵值较发作间期和正常对照组降低(P<0.017),前头部更明显。分尺度子波熵中,11尺度发作期子波熵值较发作间期和正常对照组增高(P<0.017);9尺度发作期子波熵值低于发作间期和正常对照组(P<0.017)。结论JME发作时整体子波熵降低,提示全脑活动较发作间期和正常对照变得单一而规律,全脑信息的丰富度和复杂度下降。分尺度子波熵中11尺度发作期子波熵值增高,而9尺度发作期子波熵值降低,提示发作时11尺度脑电活动频率增加,而其他尺度脑电活动频率降低。发作期各导联整体子波熵值下降程度存在差异性,前头部更明显,提示JME放电起源可能与额区皮质相关。Objective To investigate the changes in electroencephalogram(EEG)signals during seizures of juvenile myoclonic epilep-sy(JME)using wavelet entropy and explore the dynamic mechanism of JME,and to provide a better indicator for monitoring seizures.Methods The seizure EEG signals of 10 patients with JME were decomposed with Gaussian continuous wavelet transform.On this ba-sis,we analyzed the wavelet power spectrum and calculated the integral wavelet entropy(En)and individual-scale wavelet entropy[En(a)].According to the visual EEG analysis,the wavelet entropy was categorized into inter-ictal,pre-ictal and ictal phases.We ob-served the dynamic changes of wavelet entropy during the entire period of seizure of JME and compared the change pattern with normal controls.Results The integral wavelet entropy in ictal phase was significantly lower than those in inter-ictal phase and normal controls(P<0.017),especially in the frontal region.The 11th scale wavelet entropy of JME in ictal phase was significantly higher than those in inter-ictal phase and normal controls(P<0.017),while the opposite was observed for the 9th scale wavelet entropy(P<0.017).Conclusions The lower integral wavelet entropy in ictal phase of JME suggests simple and regular activity and reduced richness and complexity of the whole brain as compared with inter-ictal phase and normal controls.The increase in the 11th scale wavelet entropy and the decrease in the 9th scale wavelet entropy in ictal phase indicate increased frequency of brain electrical activity in the 11th scale and decreased frequency in other scales. The integral wavelet entropy of different leads in ictal phase decreased to various extents,and the greater decrease in the frontal region suggests the frontal cortex as a source of discharges in JME.

关 键 词：青少年肌阵挛癫痫 脑电图 子波分析 子波熵 

分 类 号：R742[医药卫生—神经病学与精神病学]