磁流体热疗在中枢神经系统部分恶性肿瘤中的研究进展  

Research advances in magnetic fluid hyperthermia for malignant tumors of the central nervous system

作　　者：姚菁青 李云涛[1] YAO Jing-Qing;LI Yun-Tao(Department of Neurology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing,Jiangsu 210011,China)

机构地区：[1]南京医科大学第二附属医院神经内科,江苏南京210011

出　　处：《国际神经病学神经外科学杂志》2020年第4期449-452,共4页Journal of International Neurology and Neurosurgery

基　　金：2016年江苏省“六大人才高峰”高层次人才C类资助项目(2016-WSN-080);2016年江苏省高层次卫生人才"六个一工程"资助项目(LGY2016019);2016年江苏省卫计委十三五“科教强卫工程”青年医学重点人才资助项目(QNRC2016677)。

摘　　要：磁流体热疗是一种非侵入性的局部热疗纳米技术,它是以磁性纳米粒子作为热介质,在外加交变磁场的作用下产热至41~46℃,升高的温度通过多种机制杀死肿瘤细胞。与传统热疗相比较,磁流体热疗具有生物安全性高、组织深度穿透、靶向选择性杀伤等诸多优点,已成为纳米医学领域的一个重要课题。该文就磁流体热疗在中枢神经系统部分恶性肿瘤研究中的最新进展做一概述。Magnetic fluid hyperthermia(MFH) is a non-invasive,nanotechnology-based local hyperthermia therapy. In MFH,magnetic nanoparticles as a heating mediator are exposed to an external alternating magnetic field and heated to 41~46℃. The high temperature kills tumor cells through a variety of mechanisms. Compared to traditional hyperthermia,MFH has several advantages including high biosafety,deep tissue penetration,targeted delivery,and selective killing,and thus has become an important topic in the field of nanomedicine. In this paper,we provide a brief review of the latest advances of MFH in the treatment of malignant tumors of the central nervous system.

关 键 词：中枢神经系统 恶性肿瘤 磁流体热疗 磁性纳米粒子 纳米医学 

分 类 号：R739.4[医药卫生—肿瘤]