铑催化的丙酮肟醚导向的苯酚的邻位烯基化反应  

Rhodium-Catalyzed ortho-Alkenylation of Phenols Directed by Acetone Oxime Ether

作　　者：刘玲玲 杨闪 韩昳 戴晨阳 史达清[1] 黄志斌[1] 赵应声[1] Liu Lingling;Yang Shan;Han Yi;Dai Chenyang;Shi Daqing;Huang Zhibin;Zhao Yingsheng(College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou 215123)

机构地区：[1]苏州大学材料与化学化工学部,苏州215123

出　　处：《有机化学》2020年第8期2394-2401,共8页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21772139,21572149);江苏省高等学校自然科学基金重大基础研究(Nos.15KJA150006,17KJA150006);江苏省杰出青年自然科学基金(No.BK2018g0041);苏州科技基础设施(No.SZS2018201708);江苏高校优势学科建设工程资助项目。

摘　　要：以弱配位中心丙酮肟醚为导向基团,Rh为催化剂,实现了一种高区域选择性的苯酚类化合物邻位烯基化反应.该策略具有反应条件温和、底物适应性广、区域选择性好等优点.为苯酚的选择性的邻位烯基化提供了一种新的有效方法.A practical rhodium-catalyzed highly regioselective ortho-alkenylation of phenolic compound under the assistance of weak coordination center acetoxime ether was developed.This strategy has advantages of simple and mild reaction conditions,wide scope of substrate and high regioselectivity.This protocol provids an efficient and new method for the regioselective ortho-alkenylation of phenols.

关 键 词：苯酚 丙酮肟醚 烯基化 

分 类 号：O621.2[理学—有机化学]