运动对阿尔茨海默病患者认知功能干预效果的meta分析  

Meta-analysis on the Effect of Exercise on the Cognitive Function of Patients with Alzheimer’s Disease

作　　者：刘军[1] 刘仁仪[1] 叶星 LIU Jun;LIU Renyi;YE Xing(School of Physical Education,China University of Geosciences(Wuhan),Wuhan 430074,Hubei,China)

机构地区：[1]中国地质大学(武汉)体育学院,湖北武汉430074

出　　处：《上海体育学院学报》2020年第10期58-67,共10页Journal of Shanghai University of Sport

基　　金：中央高校基本科研业务费专项资金“杰出人才培育基金”资助项目(CUG150607);中国地质大学(武汉)大学生基础科研训练计划项目(1810491180)。

摘　　要：目的综合评价运动对阿尔茨海默病(Alzheimer’s disease,AD)患者认知功能的干预效果,并通过比较不同类型和频率的运动对AD患者认知功能的影响,探讨运动干预AD的最佳防治方案。方法通过检索PubMed、SCI、MEDLINE和中国知网等数据库,查找相关随机对照试验,检索时间从建库起至2018年12月;按纳入与排除标准筛选文献,评价纳入文献研究方法质量后提取数据;采用RevMan 5.3软件对AD患者简易智力状态检查得分进行meta分析。结果通过筛选共纳入15篇文献,包含774例AD患者相关资料。meta分析结果显示:运动对AD患者认知功能干预效果的合并效应量落在无效线右侧[MD=1.27,95%CI(0.77,1.78),P<0.000 01];有氧与无氧结合运动[MD=1.38,95%CI(0.09,2.67),P=0.04]合并效应量值大于单纯有氧运动[MD=1.26,95%CI(0.70,1.81),P<0.000 01];高频率运动[MD=1.71,95%CI(0.11,3.30),P=0.04]合并效应量值大于低频率运动[MD=1.60,95%CI(0.86,2.34),P<0.000 1]。结论运动可有效改善AD患者的认知功能;有氧与无氧结合运动的干预效果优于单纯的有氧运动;高频率运动的干预效果优于低频率运动。Objectives To comprehensively evaluate the effect of exercise on the cognitive function of Alzheimer’s disease(AD)patients and to explore the optimal program of exercise prevention and treatment for AD patients by comparing the effects of different types and frequencies of exercise on the cognitive function in AD patients.Methods Databases such as PubMed,SCI,MEDLINE and CNKI were searched for relevant randomized controlled trials. The retrieval time was from the date of database construction to December 2018,literature was screened according to the inclusion and exclusion criteria,and the data were extracted after evaluating the quality of research methods to include the literature. Results Through screening,15 pieces of literature were used including the data of 774 patients with AD. Meta-analysis results show that the combined effect size of exercise effects on the cognitive function in patients with AD falls on the right side of the invalid line[MD=1.27,95%CI(0.77,1.78),P<0.000 01]. The combined effect size of combined aerobic and anaerobic exercise[MD=1.38,95%CI(0.09,2.67),P=0.04]is greater than the simple aerobic exercise[MD=1.26,95%CI(0.70,1.81),P<0.000 01],and the combined effect size of high frequency exercise[MD=1.71,95%CI(0.11,3.30),P=0.04] greater than the low frequency exercise [MD=1.60,95%CI(0.86,2.34),P<0.000 1]. Conclusions Exercise can effectively improve the cognitive function of AD patients;The intervention effect of combined aerobic and anaerobic exercises is better than that of aerobic exercise alone. And the intervention effect of the high frequency exercise is better than that of the low frequency exercise.

关 键 词：运动 阿尔茨海默病 认知功能 有氧运动 无氧运动 META分析 

分 类 号：G804.5[文化科学—运动人体科学]