不同年龄段女性三阴性乳腺癌化疗患者的认知功能水平分析  

Analysis of cognitive function levels of women with triple-negative breast cancer chemotherapy at different ages

作　　者：龚烨[1] 波拉提·沙依提[1] 张卫群[1] Gong Ye;Bolati·Shayiti;Zhang Weiqun(Department of Mammary Gland Thyroid,Xinjiang Uygur Autonomous Region People's Hospital,Xinjiang Urumqi 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院乳腺甲状腺科,新疆乌鲁木齐830001

出　　处：《现代肿瘤医学》2020年第19期3337-3340,共4页Journal of Modern Oncology

摘　　要：目的:探究不同年龄段女性三阴性乳腺癌化疗患者的认知功能水平。方法:收集2016年5月至2017年8月期间在我院接受化学治疗的三阴性乳腺癌患者96例,作为实验组,另收集同时间段内在我院进行治疗的非三阴性乳腺癌患者96例,作为对照组。将实验组及对照组患者按照年龄分为A组(≤40岁),B组(41~65岁),C组(>65岁),A组、B组、C组的例数分别为53例、62例、77例。比较实验组患者与对照组患者的MMSE量表、PM问卷、RM问卷得分,并采用SPSS 19.0统计学软件进行数据分析。结果:实验组患者与对照组患者的年龄、教育程度资料比较差异不具有统计学意义(P>0.05);实验组患者的MMSE量表得分低于对照组,PM量表、RM量表得分高于对照组,数据差异具有统计学意义(P<0.05)。在A组中,实验组患者的PM量表、MMSE量表、RM量表得分与对照组比较差异具有统计学意义(P<0.05),两组的教育程度比较差异不具有统计学意义(P>0.05);B组、C组中,实验组患者的PM量表、MMSE量表、RM量表得分与对照组比较差异不具有统计学意义(P>0.05)。Logistic回归分析结果显示,患者年龄、三阴性乳腺癌均是影响乳腺癌患者发生认知障碍的独立危险因素(P<0.05)。结论:乳腺癌化疗能够使患者的认知障碍呈现异质性;三阴性乳腺癌患者认知障碍的严重程度高于非三阴性乳腺癌患者;患者年龄是影响三阴性乳腺癌发生认知障碍的独立危险因素。Objective:To study the cognitive function of women with triple-negative breast cancer chemotherapy in different age groups.Methods:Ninety-six patients with triple-negative breast cancer receiving chemotherapy in our hospital from May 2016 to August 2017 were collected(experimental group).Another 96 non-triple-negative breast cancer patients were treated in our hospital during the same period as the control group.The patients in the experimental group and the control group were divided into A group(≤40 years old),B group(41 to 65 years old),C group(>65 years old),with 53 cases,62 cases,77 cases.MMSE scale,PM questionnaire and RM questionnaire scores of patients in experimental group and control group were compared and analyzed by SPSS 19. 0 statistical software.Results: There was no significant difference between the experimental group and the control group in the age and educational level( P > 0. 05). The MMSE score of the experimental group was lower than that of the control group,while the PM and RM scales were higher than those of the control group,the difference was statistically significant( P <0. 05). In group A,the scores of PM,MMSE and RM in experimental group were significantly different from those in control group( P < 0. 05). The education level of two groups was not statistically significant( P > 0. 05). In group B and group C,the scores of PM,MMSE and RM in experimental group were not statistically significant compared with those in control group( P > 0. 05). Logistic regression analysis showed that patient age and triple negative breast cancer were all independent risk factors for cognitive impairment in breast cancer patients( P < 0. 05). Conclusion: Breast cancer chemotherapy can make patients with cognitive disorders heterogeneity. The severity of cognitive impairment in triple-negative breast cancer patients is higher than non-triple-negative breast cancer patients. Age is an independe risk affecting triple-negative bereast cnancer cognitive impairment.

关 键 词：年龄 三阴性乳腺癌 化疗 认知功能 

分 类 号：R737.9[医药卫生—肿瘤]