局部放疗对Ⅳ期食管鳞癌患者生存影响的回顾性分析  

Retrospective analysis of the impact of local radiotherapy on the survival of patients with stage Ⅳ esophageal squamous cell carcinoma

作　　者：邵彦彦[1] 毕良文[1] 王海静[1] 张丽珍[1] 赵滑峰[1] 唐鹿群[1] 李欢欢[1] Shao Yanyan;Bi Liangwen;Wang Haijing;Zhang Lizhen;Zhao Huafeng;Tang Luqun;Li Huanhuan(Department of Radiotherapy,the Second Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210011,China)

机构地区：[1]南京医科大学第二附属医院放疗科,江苏南京210011

出　　处：《现代肿瘤医学》2020年第19期3361-3364,共4页Journal of Modern Oncology

摘　　要：目的:探讨局部根治剂量及姑息剂量放疗对Ⅳ期食管鳞癌患者生存的影响。方法:回顾性分析2010年1月至2016年7月我院初治的36例Ⅳ期食管鳞癌患者的总体生存时间、1年、2年及3年生存率,同时比较化疗后根治剂量放疗及姑息剂量放疗对生存时间、局部有效率和不良反应的影响。结果:36例Ⅳ期食管鳞癌患者的1年、2年、3年生存率分别为66.7%、36.1%和19.4%,总体中位生存时间为13.5个月。高剂量放疗组和低剂量放疗组的中位生存时间分别是17个月和11个月,1年、2年、3年生存率分别是81%、42.9%、28.6%和46.7%、20%、6.7%,二者的中位生存时间有统计学差异(P=0.024)。高剂量放疗组和低剂量放疗组的放疗有效率分别为71.4%和26.7%,二者之间有统计学差异(P=0.017)。两组间的白细胞减少和血小板减少程度无统计学差异(P>0.05),放射性食管炎及放射性肺炎发生率也无统计学差异(P>0.05)。结论:化疗后给予Ⅳ期食管癌患者局部病灶根治性放疗,有改善患者总体生存的趋势。Objective:To explore the impact of local radiotherapy between high dose radiotherapy group and low dose radiotherapy group on the survival of patients with stage Ⅳ esophageal squamous cell carcinoma.Methods:The overall survival,1-year,2-year and 3-year survival rate of newly diagnosed 36 patients with stage Ⅳ esophageal squamous cell carcinoma in our hospital from January 2010 to July 2016 were analyzed.The impact of local radiotherapy after chemotherapy on the median survival time,response rate and adverse reaction were compared between the two groups.Results:The median overall survival time of the 36 patients with stage Ⅳ esophageal squamous cell carcinoma was 13.5 months and 1-year,2-year and 3-year survival rate were 66.7%,36.1% and 19.4% respectively.The median survival time of high dose and low dose radiotherapy group were 17 months and 11 months.The 1-year,2-year and 3-year survival rate of high dose and low dose radiotherapy group were 81%,42.9%,28.6% and 46.7%,20%,6.7% respectively.The median survival time of the two groups had statistic difference(P=0.024).The radiotherapy response rate of the two groups were 71.4% and 26.7% respectively,and it also had statistic difference(P=0.017).The degree of leukopenia and thrombocytopenia in the two groups had no statistic difference(P>0.05).The incidence of radiation esophagitis and radiation pneumonia had no statistic difference(P> 0.05).Conclusion:The local radical radiotherapy has a tendency to improve overall survival of patients with Ⅳ esophageal squamous cell carcinoma.

关 键 词：放射治疗 食管癌 生存 

分 类 号：R735.1[医药卫生—肿瘤]