DOS、TOS及SOX方案用于胃癌新辅助化疗的疗效比较  

Comparison of three different schemes of DOS,TOS and SOX for neoadjuvant chemotherapy of gastric cancer

作　　者：赛福丁·柯尤木[1] 努热古·阿热甫 布力布·吉力斯汉[1] 唐勇[1] Saifuding·Keyoumu;Nuregu·Arefu;Bulibu·Jilisihan;Tang Yong(Department of Gastroenteroloy,Affiliated Tumor Hospital of Xinjiang Medical University,Xinjiang Urumqi 830011,China)

机构地区：[1]新疆医科大学附属肿瘤医院消化内科,新疆乌鲁木齐830011

出　　处：《现代肿瘤医学》2020年第19期3374-3377,共4页Journal of Modern Oncology

基　　金：新疆维吾尔自治区科技厅面上项目(编号:2016D01C362)。

摘　　要：目的:探讨DOS和TOS及SOX方案用于胃癌新辅助化疗的临床疗效,用来找寻胃癌新辅助化疗的优选方案。方法:选取2010年1月-2016年1月在我院行DOS和TOS及SOX方案新辅助化疗的胃癌患者135例。分别为:DOS组61例,TOS组40例,SOX组34例,各行1至4周期化疗,平均3周期,分析3种方案临床、病理分期降期率、手术切除率等情况。结果:DOS组手术切除率高于TOS组(55.7%vs 35.0%),差异有统计学意义(P<0.05)。SOX组手切除率高于TOS组(52.9%vs 35.0%),但差异无统计学意义(P>0.05),DOS组手术切除率略高于SOX组(55.7%vs 52.9%),差异无统计学意义。TOS降期率高于DOS,SOX(71.4%vs 64.7%vs 66.7%),差异无统计学意义。结论:DOS与其他两方案相比,具有更高的手术切除率,但SOX方案用于老年患者新辅助化疗中具有优势。Objective:To investigate the clinical efficacy of DOS,TOS and SOX regimens in neoadjuvant chemotherapy for gastric cancer in order to explore the optimal regimen for neoadjuvant chemotherapy of gastric cancer.Methods:One hundred and thirty-five patients with gastric cancer who underwent neoadjuvant chemotherapy with DOS and TOS and SOX in our hospital from January 2010 to January 2016 were selected,including 61 cases in DOS group,40 cases in TOS group,34 cases in SOX group,and 1 to 4 cycles of chemotherapy in each group,with an average of 3 cycles.The clinical,pathological stages and surgical excision rates of the 3 schemes were andysed.Results:The resection rate of DOS group was higher than that of TOS group(55.7% vs 35.0%).The difference was statistically significant(P<0.05).The resection rate in SOX group was higher than that in TOS group(52.9% vs 35.0%),but the difference was not statistically significant(P>0.05).The surgical resection rate in DOS group was slightly higher than that in SOX group(55.7% vs 52.9%),but the difference was not statistical significance.The declining rate of TOS was higher than that of DOS and SOX(71.4% vs 64.7% vs 66.7%),but the difference was not statistically significant.Conclusion:DOS has a higher surgical resection rate than the other two programs,but SOX regimen has advantages in neoadjuvant chemotherapy for elderly patients.

关 键 词：进展期胃癌 新辅助化疗 多西他赛 紫杉醇 替吉奥 奥沙利铂 

分 类 号：R735.2[医药卫生—肿瘤]