过渡金属催化的不对称氢化反应的国内研究进展  

Progress of Transition Metal-catalyzed Asymmetric Hydrogenation in China

作　　者：张树辛 冯宇[1,2] 范青华 ZHANG Shuxin;FENG Yu;FAN Qinghua(Beijing National Laboratory for Molecular Sciences,CAS Key Laboratory of Molecular Recognition and Function,Institute of Chemistry,Chinese Academy of Sciences(CAS),Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国科学院化学研究所北京分子科学国家研究中心,中国科学院分子识别与功能重点实验室,北京100190 [2]中国科学院大学,北京100190

出　　处：《高等学校化学学报》2020年第10期2107-2136,M0001,共31页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号:21790332,21521002,21871270)资助.

摘　　要：手性过渡金属催化剂催化的不对称氢化反应是制备光学纯手性氨基酸、手性醇、手性胺和手性酸等手性化合物的重要手段和途径.本文主要概括了近20年内中国科学家在手性膦配体及其过渡金属催化剂的设计合成及不对称催化氢化新反应两方面的研究进展,并展望了该领域的发展前景.Chiral transition metal complexes-catalyzed asymmetric hydrogenation is one of the most efficient methods for the synthesis of optically pure compounds including amino acids,alcohols,amines and acids,and has been intensively investigated in the past several decades.This review mainly summarizes the main progress of the transition metal-catalyzed asymmetric hydrogenation achieved by Chinese scientists from two aspects:(1)the design and synthesis of chiral phosphorus ligands and their transition metal catalysts;(2)catalytic asymmetric hydrogenations of new and difficult substrates including functionalized olefins,ketones,imines and heteroaromatic compounds.In addition,the challenges and prospects in the field of asymmetric hydrogenation are briefly discussed.

关 键 词：不对称氢化 手性膦配体 金属催化剂 手性化合物 

分 类 号：O621.3[理学—有机化学] O643.32[理学—化学]