正常眼压性青光眼与原发性开角型青光眼的视神经蛛网膜下隙面积差异以及与相关因素间关联分析  

Difference of optic nerve subarachnoid space area between normal tension glaucoma and primary open-angle glaucoma and its correlation with related factors

作　　者：汤志铮 吴学辉 陈学平 梁耀方 Tang Zhizheng;Wu Xuehui;Chen Xueping;Liang Yaofang(Department of Ophthalmology,Gaozhou Traditional Chinese Medicine Hospital of Guangdong Province,Guangdong Gaozhou 525200,China)

机构地区：[1]广东省高州市中医院眼科,525200

出　　处：《中国医师进修杂志》2020年第9期775-779,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的分析正常眼压性青光眼(NTG)与原发性开角型青光眼(POAG)视神经蛛网膜下隙面积(ONSSA)的差异以及其与相关因素的关联性。方法选择2016年1月至2019年5月广东省高州市中医院确诊的53例NTG患者(A组)、46例POAG患者(B组),均未接受任何治疗,另选40例健康体检者(C组),检测各组的体质量指数、血压、24 h眼压、视野缺损、视轴长度、中央角膜厚度等指标,同时进行眼部二维超声扫描并分析各组球后3~7 mm的ONSSA差异,并分析ONSSA与临床相关因素的关联性。结果A组ONSSA明显小于B组、C组[(5.07±0.83)mm^2比(6.19±0.90)、(6.57±1.43)mm^2],差异均有统计学意义(t=5.219、6.107,P<0.05)。A组的ONSSA与24 h眼压平均值、最高值均呈正相关(r=0.658、0.479,P<0.05);而B、C组ONSSA与24 h眼压平均值、最高值均无相关性(P>0.05)。三组的ONSSA与年龄、体质量指数、平均动脉压、中央角膜厚度、视野缺损以及视轴长度等因素均无相关性(P>0.05)。结论NTG患者的ONSSA较POAG患者及健康人群均降低,且NTG患者的ONSSA与24 h眼压的平均值及最高值均有相关性。Objective To investigate the optic nerve subarachnoid space area(ONSSA)in patients with normal tension glaucoma(NTG)and primary open-angle glaucoma(POAG)and its correlation with related factors.Methods Fifty-three patients with NTG(Group A)and 46 patients with POAG(Group B)were selected from January 2016 to May 2019 in Gaozhou Traditional Chinese Medicine Hospital of Guangdong Province.None of them received any treatment.Another 40 patients with health examination(Group C)were selected.Body mass index,blood pressure,24-hour intraocular pressure,visual field damage,visual axis length and central corneal thickness were measured in each group.Two-dimensional ultrasound was performed to analyze the difference of ONSSA in the retrobulbar 3 to 7 mm range in each group,and the correlation between ONSSA and clinical related factors was analyzed.Results The ONSSA in group A was significantly smaller than that in group B and group C:(5.07±0.83)mm^2 vs.(6.19±0.90)and(6.57±1.43)mm^2,the differences were statistically significant(t=5.219 and 6.107,P<0.05).ONSSA in group A was positively correlated with the mean intraocular pressure and maximum intraocular pressure of 24 hours(r=0.658 and 0.479,P<0.05),while ONSSA in group B and C was not correlated with the mean intraocular pressure and maximum intraocular pressure of 24 hours(P>0.05).ONSSA was not correlated with age,body mass index,mean arterial pressure,central corneal thickness,visual field damage and visual axis length(P>0.05).Conclusions ONSSA of NTG patients is lower than that of POAG patients and healthy people,and the ONSSA of NTG patients is correlated with the mean intraocular pressure and maximum intraocular of 24 hours.

关 键 词：青光眼 开角型 眼内压 视神经 蛛网膜下腔 

分 类 号：R775[医药卫生—眼科]