低剂量口服避孕药对妇女血凝及纤溶系统的影响  

The Effects of Low-dose Oral Contraceptives Pill on Blood Coagulation and Fibronolysis

作　　者：蒋海瑛[1] 孙丹利[1] 陈爱君[1] 桑国卫[1] 

机构地区：[1]浙江省医学科学院,杭州310013

出　　处：《中国临床药理学杂志》2000年第2期96-98,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：４５名健康育龄妇女连续服用低剂量口服避孕药９个月后观察服药早期（连续服３个月）、长期服药（连续服９个月）及停药３个月后妇女血浆中主要血凝及纤溶指标的变化，并与服药前的基础值相比较。结果显示：服药早期血小板计数（ＰＬＴ）、凝血因子Ｘ、纤维蛋白原、纤溶酶原显著升高；长期服药后除上述改变外，凝血酶原时间（ＰＴ）和部分凝血活酶时间（ＡＰＴＴ）缩短。提示长期应用低剂量口服避孕药对妇女血凝及纤溶系统具有轻微的影响。Forty-five healthy women received low-dose oral contraceptive pill for nine months. Blood samples were taken during the follicular and luteal phases of pre-treatment, and the first day of the 3rd and 9th pill cycles and 1 and 3 weeks later in both cycles, after at least 3 months nonhormonal method of contraception, blood sampling was repeated at follicular and luteal phases of a normal menstrual cycle. The result of our study is that platelet count, factorX,Plasminogen and fibrinogen increased and prothrombin time and APTT accelerated.There are slight changes on coagulation and fibrinolysis in low-dose OC users.

关 键 词：纤溶系统 口服避孕药 低剂量 血凝系统 给药方法 

分 类 号：R965[医药卫生—药理学] R979.21[医药卫生—药学]