微小甲状腺乳头状癌合并慢性淋巴细胞性甲状腺炎的临床特征和MMP-9表达  

Clinical features and MMP-9 expression of papillary thyroid carcinoma combined with chronic lymphocytic thyroiditis

作　　者：王晖 马世红 张正东 韩华中 艾志龙 WANG Hui;MA Shihong;ZHANG Zhengdong;HAN Huazhong;AI Zhilong(Department of General Surgery,Shanghai Xuhui District Central Hospital,Shanghai 200031,China)

机构地区：[1]上海市徐汇区中心医院普外科,200031 [2]复旦大学附属中山医院普外科

出　　处：《浙江医学》2020年第18期1978-1980,共3页Zhejiang Medical Journal

基　　金：江苏大学临床医学科技发展基金项目(JLY20180041);徐汇区中心医院科研课题项目(2018XHYY-10)。

摘　　要：目的探讨微小甲状腺乳头状癌(PTMC)合并慢性淋巴细胞性甲状腺炎(CLT)的临床特征和肿瘤组织基质金属蛋白酶9(MMP-9)表达的临床意义。方法选取2017年1月至2019年6月在上海市徐汇区中心医院行甲状腺切除手术的PTMC患者194例。其中单纯PTMC患者121例(PTMC组),PTMC合并CLT患者73例(PTMC合并CLT组)。回顾并收集两组患者临床病理特征资料。采用免疫组化SP法检测两组患者肿瘤组织MMP-9表达情况。结果两组患者性别、年龄、肿瘤直径、肿瘤多灶性、淋巴结转移情况及有无合并结节性甲状腺肿等病理特征比较差异均无统计学意义(均P>0.05)。PTMC组患者肿瘤组织MMP-9阳性表达率高于PTMC合并CLT组(68.60%比45.20%,P<0.05)。PTMC组、PTMC合并CLT组有淋巴结转移患者MMP-9阳性表达率均高于无淋巴结转移患者(80.00%比47.52%、77.78%比35.94%,均P<0.05)。结论PTMC合并CTL患者与单纯PTMC患者的临床特征无明显差异,但单纯PTMC患者肿瘤组织中MMP-9阳性表达率更高,这种高表达可能与淋巴结转移相关。Objective To investigate the clinical features and clinical significance of matrix metallopeptidase 9(MMP-9)of papillary thyroid carcinoma(PTMC)combined with chronic lymphocytic thyroiditis(CLT).Methods The clinical and pathological data of 194 patients with PTMC who underwent thyroidectomy from January 2017 to June 2019 in our hospital were collected,including 73 cases with CLT(PTMC with CLT group)and 121 cases without CTL(PTMC group).The clinicopathological characteristics and expression of matrix metalloproteinase9(MMP-9)were compared between two groups.Results The age,sex,tumor diameter,tumor multifocality,lymph node metastasis and the presence or absence of nodular goiter(NG)in the two groups were not statistically different(both P>0.05).The expression rate of MMP-9 in PTMC group was significantly higher than that in PTMC with CLT group[68.60%(83/121)vs.45.20%(33/73),P<0.05].The MMP-9 rate in patients with lymph node metastasis of both groups were significantly higher than that in patients without lymph node metastasis(80.00%vs.47.52%and 77.78%vs.35.94%,respectively;both P<0.05).Conclusion The MMP-9 expression in PTMC patients is higher than that in PTMC combined with CTL patients;and higher MMP-9 expression may be related to lymph node metastasis of papillary thyroid carcinoma.

关 键 词：微小甲状腺乳头状癌 慢性淋巴细胞性甲状腺炎 基质金属蛋白酶9 

分 类 号：R736.1[医药卫生—肿瘤] R581.4[医药卫生—临床医学]