急性胰腺炎后糖代谢紊乱的研究  

Study on the Disorder of Glucose Metabolism After Acute Pancreatitis

作　　者：王辉[1] 刘爱芬[2] 王晓鹏 班东杰[1] 徐世新 WANG Hui;LIU Ai-fen;WANG Xiao-peng;BAN Dong-jie;XU Shi-xin(Department of Surgery,Subjetc One,Tianjin Public Security Hospital,Tianjin 300042,China;Department of Anesthesiology,the Second Hospital of Tianjin Medical University,Tianjin 300021,China;Department of Anesthesiology,Shanxi Bethune Hospital,Taiyuan 030032,Shanxi,China)

机构地区：[1]天津市公安医院外一科,天津300042 [2]天津医科大学第二医院麻醉科,天津300021 [3]山西白求恩医院麻醉科,山西太原030032

出　　处：《医学信息》2020年第19期38-40,共3页Journal of Medical Information

基　　金：天津市公安局科研项目(编号:2017KYSGAY021)。

摘　　要：急性胰腺炎(AP)是临床常见的急腹症,由于胰腺受损,胰岛细胞发生炎症反应而死亡,导致胰腺功能障碍,甚至功能丧失。而胰岛素分泌不足及胰岛素抵抗均会造成血糖代谢紊乱,影响患者的日常生活和身体健康。目前,多项研究显示胰岛素抵抗(IR)是AP后新发糖代谢紊乱的主要机制,其中AP后促炎细胞因子、脂质代谢与IR密切相关,且胰腺功能不全也可能是AP后糖代谢紊乱的因素。本文就AP后糖代谢紊乱的影响因素、AP与IR的关系、AP与胰腺功能不全的关系进行综述,以期为预防临床AP后新发糖代谢紊乱提供理论依据。Acute pancreatitis(AP)is a common clinical acute abdomen.Due to the damage of the pancreas,the islet cells die due to inflammation,leading to pancreatic dysfunction and even loss of function.Insufficient insulin secretion and insulin resistance can cause blood glucose metabolism disorders,affecting the daily life and health of patients.At present,many studies have shown that insulin resistance is the main mechanism of new glucose metabolism disorders after AP,and proinflammatory cytokines and lipid metabolism are closely related to IR,and pancreatic dysfunction may also be a factor of glucose metabolism disorder after AP.This article reviews the influencing factors of glucose metabolism disorders after AP and the relationship between AP and IR,in order to provide a theoretical basis for preventing new glucose metabolism disorders after clinical AP.

关 键 词：急性胰腺炎 糖代谢紊乱 血糖 糖尿病 

分 类 号：R576[医药卫生—消化系统]