角膜缘微环境细胞的研究进展  

Recent advances of limbal niche cells

作　　者：徐玲娟 李莘 王玮[1] 李贵刚[1] Xu Lingjuan;Li Shen;Wang Wei;Li Guigang(Department of Ophthalmology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院眼科,武汉430030

出　　处：《国际眼科纵览》2020年第4期228-231,共4页International Review of Ophthalmology

基　　金：国家自然科学基金(81470606);湖北省自然科学基金(2019CFB667)。

摘　　要：角膜缘微环境细胞(limbal niche cell,LNC)是近年来发现的一种来自于角膜缘干细胞微环境且具有血管内皮祖细胞和间充质干细胞特性的多能干细胞。LNC具有分化为血管内皮细胞、角膜上皮细胞、角膜基质细胞等多种细胞的潜能。体外实验发现,LNC在三维立体培养环境中可以维持角膜缘干细胞的特性;动物实验发现,LNC可以预防和治疗碱烧伤所致的角膜缘干细胞缺乏。LNC还可以促进角膜基质的无瘢痕修复,减少修复过程中的新生血管化,提示其可以重建角膜基质。因此,在角膜缘干细胞缺乏、角膜基质损伤等疾病的治疗中,LNC可能是一种理想的治疗细胞。Limbal niche cells(LNCs)are a kind of mesenchymal stem cells isolated from limbal stem cells microenvironment.These niche cells display a phenotype typical of vascular endothelial progenitor cells and mesenchymal stem cells.LNCs support limbal epithelial stem cells viability and exhibit a potential to differentiate to multiple cell types such as vascular endothelial cells,corneal epithelial cells,corneal stromal cells and so on.Therefore,they can prevent or treat limbal stem cell deficiency caused by alkaline burns in animal experiments.LNCs have also shown the ability to remodel pathological stromal tissue,suppressing inflammation and neovascularization and restoring transparency.All these abilities give LNCs the potential for allograft or even autologous stem cells treatment for corneal wound healing and other corneal diseases.

关 键 词：角膜缘微环境细胞 间充质干细胞 角膜缘干细胞缺乏 

分 类 号：R772.2[医药卫生—眼科]