基于决策树优化的伏立康唑个体化用药  

Exploration of Individualized Medication of Voriconazole Based on Decision Tree Model

作　　者：邓体瑛 董俊丽 刘剑敏 黄鹤归 李璐璐 张恩景[2] DENG Tiying;DONG Junli;LIU Jianmin;HUANG Hegui;LI Lulu;ZHANG Enjing(Department of Pharmacy,Wuhan Hospital of Traditional Chinese and Western Medicine,Wuhan No.1 Hospital,Wuhan 430022,China;Department of Pharmacy,Tongren Hospital of Wuhan University(the Third Hospital of Wuhan City),Wuhan 430060,China)

机构地区：[1]武汉市中西医结合医院(武汉市第一医院)药学部,武汉430022 [2]武汉大学附属同仁医院(武汉市第三医院)药学部,武汉430060

出　　处：《医药导报》2020年第10期1428-1432,共5页Herald of Medicine

摘　　要：目的通过决策树优化伏立康唑的个体化用药,为决策伏立康唑用药方案提供更好的建议,保障伏立康唑的用药疗效及安全性。方法临床药师考量相关因素(肝功能、合并用药、基因型)获取相关资料,进行信息整合,建立伏立康唑个体化给药决策树,并依据决策树予以初始治疗方案,再根据血药浓度进行后期调整。结果根据决策树,对伏立康唑用药前后相关影响因素进行全面分析,综合权衡,为临床提供安全有效的用药建议。结论应用伏立康唑决策树能为临床提供便捷、精准的用药方案,保障伏立康唑的疗效和安全性,体现临床药师的工作价值。Objective Decision tree optimization of personalized medicine for voriconazole,to provide better suggestions for decision-making of voriconazole,and to ensure the efficacy and safety of voriconazole.Methods The clinical pharmacist carefully considered the relevant factors(liver function,combined medication,genotype)to obtain relevant data,integrated the information,establish the decision tree for individualized administration of voriconazole and made the initial plan according to the decision tree,and then adjusted it later based on the blood drug concentration.Results According to the decision tree model,a comprehensive analysis of related factors before and after the administration of voriconazole was conducted,and a comprehensive trade-off was made to provide safe and effective medication recommendations for clinical use.Conclusion The application of voriconazole decision tree can provide a convenient and accurate medication plan for the clinic,ensure the efficacy and safety of voriconazole,and reflect the work value of clinical pharmacists.

关 键 词：伏立康唑 个体化用药 决策树 

分 类 号：R978[医药卫生—药品]