曲美布汀联合奥美拉唑肠溶片、双歧杆菌三联活菌胶囊治疗胃食管反流病的临床效果及对肠道菌群的影响  

Clinical effect of trimebutine combined with omeprazole enteric-coated tablets and bifidobacterium triple viable capsules in the treatment of gastroesophageal reflux disease and its influence on intestinal flora

作　　者：梁聪 陈张琴[1] 吴颖[1] 王丽梅[1] 尚键 LIANG Cong;CHEN Zhangqin;WU Ying;WANG Limei;SHANG Jian(Respiratory and Gastroenterology Department,the Second People's Hospital of Shaanxi,Xi'an 710000;Chinese People's Liberation Army 96783 Troops,Huaihua 418000,China)

机构地区：[1]陕西省第二人民医院呼吸消化内科,陕西西安710000 [2]中国人民解放军96783部队,湖南怀化418000

出　　处：《临床医学研究与实践》2020年第27期48-50,共3页Clinical Research and Practice

摘　　要：目的探讨曲美布汀联合奥美拉唑肠溶片、双歧杆菌三联活菌胶囊治疗胃食管反流病的临床效果及对肠道菌群的影响。方法选取我院2017年10月至2019年10月收治的90例胃食管反流病患者,按随机数字表法将其分为研究组(n=45,曲美布汀+奥美拉唑肠溶片+双歧杆菌三联活菌胶囊)和对照组(n=45,奥美拉唑肠溶片+双歧杆菌三联活菌胶囊)。比较两组的治疗效果。结果研究组的治疗总有效率高于对照组(P<0.05)。治疗后,研究组的DCI高于对照组,GerdQ评分低于对照组(P<0.05)。治疗后,两组的肠球菌、肠杆菌数量均降低,双歧杆菌、乳酸杆菌数量均升高,且研究组优于对照组(P<0.05)。治疗后,两组的血清SOD水平均升高,LPO水平均降低,且研究组优于对照组(P<0.05)。结论曲美布汀联合奥美拉唑肠溶片、双歧杆菌三联活菌胶囊治疗胃食管反流病的临床效果显著,可缓解患者临床症状,改善食管收缩功能及肠道菌群状态,减轻胃、食管黏膜氧化应激反应,值得临床应用。Objective To investigate the clinical effect of trimebutine combined with omeprazole enteric-coated tablets and bifidobacterium triple viable capsules in the treatment of gastroesophageal reflux disease and its influence on intestinal flora.Methods A total of 90 patients with gastroesophageal reflux disease admitted in our hospital from October 2017 to October 2019 were selected and divided into study group(n=45,trimebutine+omeprazole enteric-coated tablets+bifidobacterium triple viable capsules)and control group(n=45,omeprazole enteric-coated tablets+bifidobacterium triple viable capsules)according to random number table method.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment of the study group was higher than that of the control group(P<0.05).After treatment,the DCI of the study group was higher than that of the control group,and GerdQ score was lower than that of the control group(P<0.05).After treatment,the quantities of Enterococcus and Enterobacteriaceae in the two groups decreased,and the quantities of Bifidobacterium and Lactobacillus increased,and those in the study group were better than the control group(P<0.05).After treatment,the serum SOD level of the two groups increased,and LPO level decreased,and those in the study group were better than the control group(P<0.05).Conclusion Trimebutine combined with omeprazole enteric-coated tablets and bifidobacterium triple viable capsules in the treatment of gastroesophageal reflux disease has a significant clinical effect,it can relieve the clinical symptoms of patients,improve the esophageal contractile function and intestinal flora status,and reduce the oxidative stress reaction of gastric and esophageal mucosa,which is worthy of clinical application.

关 键 词：胃食管反流病 曲美布汀 奥美拉唑肠溶片 双歧杆菌三联活菌胶囊 肠道菌群 

分 类 号：R573.9[医药卫生—消化系统]