Prostate volume does not provide additional predictive value to prostate health index for prostate cancer or clinically significant prostate cancer:results from a multicenter study in China  

作　　者：Da Huang Yi-Shuo Wu Ding-Wei Ye Jun Qi Fang Liu Brian T Helfand Siqun L Zheng Qiang Ding Dan-Feng Xu Rong Na Jian-Feng Xu Ying-Hao Sun 

机构地区：[1]Department of Urology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Department of Urology,Huashan Hospital,Fudan University,Shanghai 200040,China [3]Fudan Institute of Urology,Huashan Hospital,Fudan University,Shanghai 200040,China [4]Department of Urology,Shanghai Cancer Center,Fudan University,Shanghai 200032,China [5]Department of Urology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China [6]Division of Urology,NorthShore University Health System,Evanston,IL 60201,USA [7]Program for Personalized Cancer Care,NorthShore University Health System,Evanston,IL 60201,US A [8]Departm ent of Urology,Shanghai Changhai Hospital,The Second Military Medical University,Shanghai 2CXD433,China.

出　　处：《Asian Journal of Andrology》2020年第5期539-543,共5页亚洲男性学杂志（英文版）

基　　金：by grants from the innovation grant by Shanghai Hospital Development Center(SHDC12015105)to Jianfeng Xu;the National Natural Science Foundation of China(Grant No.81772741);Shanghai Rising-Star Program(Grant No.18QA1402800);the“Chen Guang”project supported by Shanghai Municipal Education Commission;Shanghai Education Development Foundation;Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(Grant No.20181701)to Rong Na.

摘　　要：To evaluate whether prostate volume(PV)would provide additional predictive utility to the prostate health index(phi)for predicting prostate cancer(PCa)or clinically significant prostate cancer,we designed a prospective,observational multicenter study in two prostate biopsy cohorts.Cohort 1 included 595 patients from three medical centers from 2012 to 2013,and Cohort 2 included 1025 patients from four medical centers from 2013 to 2014.Area under the receiver operating characteristic curves(AUC)and logistic regression models were used to evaluate the predictive performance of PV-based derivatives and models.Linear regression analysis showed that both total prostate-specific antigen(tPSA)and free PSA(fPSA)were significantly correlated with PV(all P<0.05).[-2]proPSA(p2PSA)was significantly correlated with PV in Cohort 2(P<0.001)but not in Cohort 1(P=0.309),while no significant association was observed between phi and PV.When combining phi with PV,phi density(PHID)and another phi derivative(PHIV,calculated as phi/PV°5)did not outperform phi for predicting PCa or clinically significant PCa in either Cohort 1 or Cohort 2.Logistic regression analysis also showed that phi and PV were independent predictors for both PCa and clinically significant PCa(all P<0.05);however,PV did not provide additional predictive value to phi when combining these derivatives in a regression model(all models vs phi were not statistically significant,all P>0.05).In conclusion,PV-based derivatives(both PHIV and PHID)and models incorporating PV did not improve the predictive abilities of phi for either PCa or clinically significant PCa.

关 键 词：China prostate cancer prostate health index prostate volume 

分 类 号：R737.25[医药卫生—肿瘤]