分化抑制因子1在胃癌组织中的表达及其临床意义  

Expression and clinical significance of inhibitor of differentiation-1 in gastric cancer

作　　者：蔡重阳 王凯诚[1] 赵金锋[1] 翟路路 Cai Chongyang;Wang Kaicheng;Zhao Jinfeng;Zhai Lulu(Department of General Surgery,Hangzhou Hospital of Traditional Chinese Medicine,Zhejiang Hangzhou 310007,China;Department of General Surgery,Renmin Hospital of Wuhan University,Hubei Wuhan 430060,China)

机构地区：[1]杭州市中医院外一科,浙江杭州310007 [2]武汉大学人民医院普外科,湖北武汉430060

出　　处：《中国医刊》2020年第10期1086-1088,共3页Chinese Journal of Medicine

基　　金：浙江省基础公益研究项目(LGF19H290004)。

摘　　要：目的探究分化抑制因子1(inhibitor of differentiation 1,Id-1)在胃癌中的表达及其临床意义。方法选取2012年1月至2018年1月杭州市中医院收治的90例胃癌患者的组织标本和临床病理资料,采用免疫组化染色评估Id-1在胃癌组织及癌旁组织中的表达情况,统计分析Id-1表达与胃癌患者临床病理特征及生存时间的关系。结果胃癌组织中Id-1的阳性表达率(83.3%)明显高于与癌旁组织(26.7%),差异有显著性(P<0.05)。胃癌组织中Id-1的表达与肿瘤浸润深度、分化程度、淋巴结转移及临床分期有关(P<0.05),而与年龄、性别及肿瘤直径无明显关联。生存期低于2年的胃癌患者Id-1阳性表达率(87.2%)高于生存期大于2年的患者(46.5%),差异有显著性(P<0.05)。结论Id-1在胃癌组织中高表达,并与肿瘤浸润深度、分化程度、淋巴结转移、临床分期及生存时间有关,可作为评价胃癌恶性程度的指标。Objective To explore the expression and clinical significance of differentiation inhibitor-1(Id-1)in gastric cancer.Method Tissue specimens and clinicopathological data of 90 patients with gastric cancer admitted to hangzhou hospital of traditional chinese medicine from January 2012 to January 2018 were selected,and immunohistochemical staining was used to evaluate the expression of Id-1 in gastric cancer tissues and adjacent tissues.The relationship between Id-1 expression and clinicopathological characteristics,and survival time of gastric cancer patients was statistically analyzed.Result The positive expression rate of Id-1 in gastric cancer tissues was significantly higher than that in paracancer tissues(83.3%vs.26.7%,P<0.05).The expression of Id-1 in gastric cancer tissue was significantly related to the depth of tumor invasion,degree of differentiation,lymph node metastasis and clinical stage(P<0.05),but not significantly related to age,gender and tumor diameter.The positive expression rate of Id-1 in gastric cancer survivors within 2 years was higher than that in gastric cancer survivors over 2 years(87.2%vs.46.5%,P<0.05).Conclusion Id-1 is highly expressed in gastric cancer tissues,and is correlated with the depth of tumor invasion,degree of differentiation,lymph node metastasis,clinical stage and short survival time.It can be used as a biomarker to evaluate the malignant degree and poor prognosis of gastric cancer.

关 键 词：胃癌 分化抑制因子1 胃黏膜 病理 

分 类 号：R735.2[医药卫生—肿瘤]