心脏转移性肿瘤临床病理分析  

Clinicopathologic features of metastatic cardiac tumors

作　　者：韩冬 杨小兵[2] 沈恬 田智丹[2] 张同海[2] 王劲松[2] 赵有财[2] HAN Dong;YANG Xiao-bing;SHEN Tian;TIAN Zhi-dan;ZHANG Tong-hai;WANG Jin-song;ZHAO You-cai(Department of Pathology,Gaochun People’s Hospital,Nanjing,211300,China;Department of Pathology,Nanjing Medical University Affiliated Nanjing Hospital/Nanjing First Hospital,Nanjing 210006,China)

机构地区：[1]南京市高淳人民医院病理科,南京高淳211300 [2]南京医科大学附属南京医院(南京市第一医院)病理科,南京210006

出　　处：《诊断病理学杂志》2020年第8期560-563,共4页Chinese Journal of Diagnostic Pathology

基　　金：南京市医学科技发展项目(YKK18098)。

摘　　要：目的探讨心脏转移性肿瘤(CM)的临床病理学特征,评估其发病率,以提高对该病的认识。方法回顾性分析2016-01—2019-11在南京市第一医院收治的4例CM患者的临床资料及病理学特征,并复习相关文献。结果心脏肿瘤57例,占同时期我院心脏手术病例的1.09%。其中心脏原发性肿瘤53例,心脏转移性肿瘤4例,分别占同时期我院心脏手术病例的1.01%和0.08%。4例CM患者中,男性2例,女性2例。发病年龄52~73岁,平均年龄62岁。分别来源于口腔肌上皮癌、肺腺癌、肝细胞癌和胸腺鳞状细胞癌。发生于右心房2例,左心房1例,右心室1例。组织学形态与原发肿瘤相似,免疫组化标记进一步证实肿瘤特征。口腔肌上皮癌转移至心脏系文献中首次报道。结论心脏转移性肿瘤原发灶来源广泛,多累及右心腔;仔细观察肿瘤组织形态学特征、免疫组化染色特征并结合临床病史有助于病理医师做出正确的诊断。Objective To investigate the clinicopathological characteristics and to estimate the incidence of cardiac metastases in order to improve the understanding of the disease.Methods The clinicopathological data of 4 cases of cardiac metastases treated at Nanjing First Hospital,from Januuary 2016 to November 2019,were retrospectively analyzed,and the related literature were reviewed.Results There were 57 cases of cardiac tumors,accounting for 1.09% of all cardiac surgery cases in our hospital in the same period,including 53 cases of primary cardiac tumors and 4 cases of cardiac metastases,accounting for 1.01% and 0.08% of all cardiac surgery cases in our hospital in the same period,respectively.Among the 4 patients with cardiac metastases,there were 2 males and 2 females.The mean ages of 4 cases were 62 years(range,52~73 years),which originated from oral myoepithelial carcinoma,lung adenocarcinoma,hepatocellular carcinoma and thymic squamous cell carcinoma,respectively.It involved right atrium in 2 cases,left atrium and right ventricle in 1 case respectively.The histological morphology of cardiac metastases was similar to that of the primary tumors,and it was demonstrated further with immunohistochemistry.Metastasis of oral myoepithelial carcinoma to the heart was first reported in the literature.Conclusion Cardiac metastases arise from different sources,mostly involving the right cardiac cavity.It is helpful for the pathologists to make a correct diagnosis by observing the characteristics of tumor histomorphology,immunohistochemistry and clinical history.

关 键 词：心脏肿瘤 转移癌 病理诊断 

分 类 号：R732.1[医药卫生—肿瘤]