短期康复治疗对急性脑梗死患者血液高凝状态的影响  

Effect of short-term rehabilitation on on blood hypercoagulability in patients with acute cerebral infarction

作　　者：谭经 彭晓华[1] 李开庭[1] 孔渝菡[1] 余和平[1] TAN Jing;PENG Xiaohua;LI Kaiting;KONG Yuhan;YU Heping(Department of Rehabilitation Medicine,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院康复医学科,重庆400016

出　　处：《国际检验医学杂志》2020年第19期2344-2347,共4页International Journal of Laboratory Medicine

基　　金：重庆市卫健委卫生适宜技术推广项目(2018jstg007)。

摘　　要：目的探讨短期康复治疗对急性脑梗死患者血液高凝状态的影响。方法选取2017年9月至2018年10月该院收治的符合纳入标准的急性脑梗死患者133例,按是否进行早期康复分为治疗组(100例)和对照组(33例)。比较康复治疗1周后两组患者凝血指标的差异。结果康复治疗1周后,治疗组患者凝血酶原时间(PT)、凝血酶时间(TT)、D-二聚体(D-D)和纤维蛋白降解产物(FDP)水平明显低于治疗前,纤维蛋白原(FIB)水平明显高于治疗前,差异有统计学意义(P<0.05);其余凝血指标与治疗前比较,差异均无统计学意义(P>0.05)。对照组患者FIB、D-D和FDP水平明显高于治疗前,TT明显低于治疗前,差异有统计学意义(P<0.05),其余凝血指标差异无统计学意义(P>0.05)。组间比较显示,随访1周后,治疗组患者FIB、D-D和FDP明显低于对照组,差异有统计学意义(P<0.05),其余凝血指标差异均无统计学意义(P>0.05)。治疗组患者住院期间下肢静脉血栓(DVT)发生率低于对照组,但差异无统计学意义(P>0.05)。结论短期康复治疗在脑梗死急性期是安全的,且能改善患者血液高凝状态。Objective To observe the effect of short-term rehabilitation on blood hypercoagulability in patients with acute cerebral infarction.Methods A total of 133 patients with acute cerebral infarction in the hospital from September 2017 to October 2018 were selected.The patients were divided into the treatment group(100 cases)and the control group(33 cases)according to whether they had received short-term rehabilitation.The differences of coagulation indexes between the two groups after 1 week of rehabilitation treatment were compared.Results After 1 week of rehabilitation treatment,prothrombin time(PT),thrombin time(TT),D-dimer(D-D)and fibrinogen degradation product(FDP)in the treatment group were significantly lower than the pre-treatment,and fibrinogen(FIB)was significantly higher than the pre-treatment(P<0.05),and there was no significant difference in other coagulation indicators(P>0.05).In the control group,FIB,D-D and FDP levels were significantly higher than the pre-treatment,TT were significantly lower than the pre-treatment(P<0.05),and there was no significant difference in other coagulation indicators(P>0.05).The incidence of DVT in the treatment group was lower than that in the control group,and there was no significant difference in other coagulation indicators(P>0.05).Conclusion Short-term rehabilitation treatment is safe in the acute stage of cerebral infarction,and short-term rehabilitation treatment could ameliorate the hypercoagulability of patients′blood.

关 键 词：急性脑梗死 康复治疗 凝血功能 静脉血栓形成 

分 类 号：R743.3[医药卫生—神经病学与精神病学]