血小板相关生物活性物质在胃癌转移中的研究进展  

Research progress of platelet-related bioactive substances in gastric cancer metastasis

作　　者：周阳(综述)[1] 孙轶华(审校)[1] ZHOU Yang;SUN Yihua(Department of Clinical Laboratory,Cancer Hospital Affiliated to Harbin Medical University,Harbin,Heilongjiang 150000,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院检验科,黑龙江哈尔滨150000

出　　处：《国际检验医学杂志》2020年第19期2418-2422,共5页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81772253)。

摘　　要：胃癌是全球第五大常见癌症,晚期胃癌患者病死率约为70%。由于胃癌的晚发性和症状非特异性,大部分胃癌患者就诊时即已发展至晚期阶段,且已发生转移。血小板在肿瘤转移过程中发挥着重要作用。在肿瘤微环境中,活化后的血小板可通过旁分泌和直接接触的方式与肿瘤细胞相互作用,提高转移过程中肿瘤细胞的存活率,并分泌众多支持肿瘤生长和血管生成的生物活性物质,为肿瘤细胞创造良好的转移前微环境。Gastric cancer is the fifth most common cancer in the world,and the mortality rate of patients with advanced gastric cancer is about 70%.Due to the late onset and non-specific symptoms of gastric cancer,the majority of patients with gastric cancer have already developed to the advanced stage at the time of consulation and the tumors have metastasized.Platelets play an important role in tumor metastasis.In the tumor microenvironment,activated platelets can interact with tumor cells through paracrine and direct contact to improve the survival rate of tumor cells in the process of metastasis,and secrete a large number of bioactive substances supporting tumor growth and angiogenesis,thus creating a good pre-metastasis microenvironment for tumor cells.

关 键 词：血小板 胃癌 肿瘤微环境 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]