Complexity of Gold(Ⅲ)Ion With Cefotaxime and Cefepime Drugs:Spectroscopic,Antimicrobial and Antitumor Discussions  

作　　者：Lamia A Albedair Samar O Aljazzar Mohamed I Kobeasy Moamen S Refat 

机构地区：[1]College of Science,Princess Nourah bint Abdulrah man University,Department of Chemistry,Saudi Arabia [2]Department of Biochemistry,Faculty of Agriculture,Cairo University,Giza,Egypt [3]Department of Chemistry,Faculty of Science,Taif University,Al-Hawiah,Taif 21974,Saudi Arabia [4]Department of Chemistry,Faculty of Science,Port Said University,Port Said,Egypt

出　　处：《光谱学与光谱分析》2020年第10期3315-3320,共6页Spectroscopy and Spectral Analysis

基　　金：the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University,through the Research Funding Program(#RFP-1440-3)。

摘　　要：The availability of chemical and biological data presented in this paper is the basis for understanding not only the current state of anti-cancer drugs based on gold(Ⅲ),but also the rationale for strategies for future drug design.New Au(Ⅲ)nanosized complexes of cefotaxime(ceph-3)and cefepime(ceph-4)ligands as a 3rd and 4th of cephalosporin generation drugs were synthesized.Gold(Ⅲ)complexes were discussed based on the elemental,molar conductance,thermal and magnetic moment measurements as well as spectral(FTIR,1HNMR,UV-Vis,and XRD)techniques.FT-IR spectra revealed that the ceph-3 and ceph-4 ligands reacted as a bidentate ligands through carboxylate oxygen andβ-lactam oxygen groups.The analytical analysis confirm that the molar ratio is 1∶1(Au 3+/ceph)with general formula[Au(L)(Cl)2]where L=ceph-3 or ceph-4.The structures of Au(Ⅲ)complexes were presence as a square planar geometry.X-ray diffraction patterns referred to a crystalline nature for all synthesized complexes.TEM analyses confirmed that the synthetic gold(Ⅲ)complexes have a nanosized particles.In vitro antimicrobial activities of Au(Ⅲ)complexes were evaluated towards two types of bacteria(G+&G-).The antitumor activities of gold(Ⅲ)complexes are appraised against breast(MCF-7)and colorectal adenocarcinoma(Caco-2)cell lines,which means that the two complexes may consider promising anticancer drugs.

关 键 词：Cefotaxime sodium Cefepime hydrochloride COMPLEXITY Gold(Ⅲ)ions Nanoscale Structure ANTICANCER 

分 类 号：O433.5[机械工程—光学工程]